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The aim of the present study was to assess the prevalence and molecular epidemiology of <jats:italic>Parechovirus<\/jats:italic> in Norwegian infants, as well as to investigate whether the presence of virus correlated with symptoms of infection. A group of 102 infants was longitudinally followed: 51 infants with a high genetic risk for type 1 diabetes (aged 3\u201335 months), and 51 children without this genotype (aged 3\u201312). Stool samples were obtained each month, and symptoms of infection were recorded regularly on questionnaires. Human parechovirus was detected in 11.3% of 1,941 samples examined by real\u2010time RT\u2010PCR. There was a distinct seasonality, peaking from September to December. By 12 months of age, 43% of the infants had had at least one infection, while 86% of the infants had encountered the virus by the end of the second year. Based on the VP1 sequence, human parechovirus 1 was the most prevalent type (76%), followed by human parechovirus 3 (13%), human parechovirus 6 (9%), an unclassified human parechovirus (1%), and human parechovirus 2 (1%). Ljungan virus, a murine parechovirus, was examined with a separate real\u2010time RT\u2010PCR, but no virus was detected. There was no significant association between infections and the following symptoms: coughing, sneezing, fever, diarrhea or vomiting. In conclusion, human parechovirus infects frequently infants at an early age without causing disease. J. Med. Virol. 80:1835\u20131842, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21283","type":"journal-article","created":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T15:32:09Z","timestamp":1219332729000},"page":"1835-1842","source":"Crossref","is-referenced-by-count":97,"title":["Longitudinal observation of parechovirus in stool samples from Norwegian 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