{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:51:32Z","timestamp":1788306692943,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T00:00:00Z","timestamp":1219104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are previous indications that transplacental transmission of cytomegalovirus (CMV), parvovirus B19 (PB19) and herpes simplex virus types 1 and 2 (HSV\u20101\/2) cause fetal infections, which may lead to fetal death. In a prospective case\u2013control study we examined the incidence of these viruses in intrauterine fetal death and their association with fetal and placenta pathological findings. Molecular assays were performed on placenta tissue extracts of 62 fetal deaths and 35 controls for the detection of CMV, PB19 and HSV\u20101\/2 genomes. Formalin\u2010fixed, paraffin\u2010embedded liver, spleen and placenta tissues of fetal death cases were evaluated histologically. Thirty\u2010four percent of placental specimens taken from intrauterine fetal deaths were positive for any of the three viruses (16%, 13%, and 5% positive for CMV, PB19, and HSV\u20101\/2, respectively), whereas only 6% of those taken from full term newborns were positive (<jats:italic>P<\/jats:italic>\u2009=\u20090.0017). No dual infection was observed. This difference was also observed when fetal deaths with a gestational age &lt;20 weeks or a gestational age &gt;20 weeks were compared with the controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.025 and <jats:italic>P<\/jats:italic>\u2009=\u20090.0012, respectively). Intrauterine death and the control groups differed in the detection rate of CMV DNA (16% and 3%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.047), which was more pronounced in a gestational age &gt;20 weeks (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). Examination of the pathological findings among the PCR\u2010positive and PCR\u2010negative fetal deaths revealed that hydrops fetalis and chronic villitis were more common among the former group (<jats:italic>P<\/jats:italic>\u2009=\u20090.0003 and <jats:italic>P<\/jats:italic>\u2009=\u20090.0005, respectively). In conclusion, an association was detected between viral infection and fetal death, which was more pronounced in the advanced gestational age. Fetal hydrops and chronic villitis were evidently associated with viral DNA detection in cases of intrauterine death. J. Med. Virol. 80:1776\u20131782, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21293","type":"journal-article","created":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T15:32:09Z","timestamp":1219332729000},"page":"1776-1782","source":"Crossref","is-referenced-by-count":87,"title":["Detection of cytomegalovirus, parvovirus B19 and herpes simplex viruses in cases of intrauterine fetal death: Association with pathological findings"],"prefix":"10.1002","volume":"80","author":[{"given":"Garyfallia","family":"Syridou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Spanakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Konstantinidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia\u2010Theophano","family":"Piperaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Kafetzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstratios","family":"Patsouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Antsaklis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Tsakris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11583.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2004.11.014"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711123172002"},{"key":"e_1_2_1_5_1","unstructured":"Confidential Enquiry into Maternal and Child Health (CEMACH).2005.Stillbirth neonatal and post\u2010neonatal mortality 2000\u20132003 England Wales and Northern Ireland. Available at:http:\/\/www. cemach.org.uk."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/sper.2002.29836"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2001.00314.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.940"},{"key":"e_1_2_1_9_1","first-page":"1030","article-title":"Herpes simplex virus type\u20102 infection in pregnancy: No risk of fetal death: Results from a nested case\u2010control study within 35,940 women","volume":"109","author":"Eskild A","year":"2002","journal-title":"Br J Obstetr Gynaecol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004300050063"},{"key":"e_1_2_1_11_1","first-page":"251","article-title":"Chronic villitis, chronic chorioamnionitis, and maternal floor infraction","volume":"10","author":"Gersell DJ","year":"1993","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00470-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.16.2.79.94"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.485-505.2002"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000024940"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(99)00055-7"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30189-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/313929"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/342575"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200212000-00009"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/107710497174895"},{"key":"e_1_2_1_22_1","first-page":"377","article-title":"Severe nonimmune hydrops fetalis and congenital corneal opacification secondary to human parvovirus B19 infection. A case report","volume":"44","author":"Plachouras N","year":"1999","journal-title":"J Reprod Med"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020701813792"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1128\/JCM.37.5.1352-1355.1999","article-title":"Laboratory diagnosis of common viral infections of the central nervous system by using a single multiplex screening assay","volume":"37","author":"Read SJ","year":"1999","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083906"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2003.09.005"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.05.025"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199702000-00004"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90681-V"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.01.015"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.3.4.651"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140305"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04647-X"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1997.2651"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38319"},{"key":"e_1_2_1_36_1","first-page":"995","article-title":"Investigation of parvovirus B19 in cardiac tissue from patients with congenital heart disease","volume":"112","author":"Wang X","year":"1999","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90561-8"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.21293","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.21293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T21:16:04Z","timestamp":1699996564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.21293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,21]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1002\/jmv.21293"],"URL":"https:\/\/doi.org\/10.1002\/jmv.21293","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,21]]}}}