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The presence of GBV\u2010C RNA was determined in serum samples of 106 patients infected with HIV by reverse transcriptase\u2010nested polymerase chain reaction. GBV\u2010C genotypes were determined by direct sequencing. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti\u2010HBs), hepatitis C antibody (anti\u2010HCV), alanine aminotransferase (ALT) levels, HIV viral load and CD4<jats:sup>+<\/jats:sup> count were also tested in all patients. The overall prevalence of GBV\u2010C infection was 11.3% in HIV patients. There was no significant difference between patients with and without GBV\u2010C infection regarding age, sex, route of transmission, viral load, ALT levels, HBV and HCV co\u2010infection and treatment with antiretroviral drugs. 66.7% of patients with GBV\u2010C had a CD4<jats:sup>+<\/jats:sup> count \u2265200 and 33.3% had a CD4<jats:sup>+<\/jats:sup> count &lt;200 cells\/mm<jats:sup>3<\/jats:sup>. Phylogenetic analysis revealed that all GBV\u2010C isolates were genotype 2, and classified as subtype 2a. GBV\u2010C infection is relatively common in patients infected with HIV. The prevailing GBV\u2010C genotype 2a in this study group concurred with reports from other parts of the Middle East. J. Med. Virol. 80:1941\u20131946, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21314","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T06:31:05Z","timestamp":1222237865000},"page":"1941-1946","source":"Crossref","is-referenced-by-count":9,"title":["Frequency and genotype of GB virus C among Iranian patients infected with 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