{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:48:16Z","timestamp":1761630496046},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,9,23]],"date-time":"2008-09-23T00:00:00Z","timestamp":1222128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, the long\u2010term (&gt;3 years) efficacy of combination therapy for hepatitis B virus (HBV) recurrence and the associated factors were investigated. One hundred and sixty\u2010five consecutive HBsAg\u2010positive patients (92 with liver cirrhosis, 73 with hepatocellular carcinoma; HCC) who underwent liver transplantation were assessed with a median follow\u2010up time of 40 months. One hundred and twenty\u2010one patients (121\/165, 73.3%) were treated with lamivudine before transplantation for a mean of 8.4 months (range 0.1\u201372 months). The post\u2010transplantation treatment protocol consisted of a high dose intravenous hepatitis B immunoglobulin (HBIg) followed by a low dose intramuscular HBIg and lamivudine combination therapy. Seven (4.2%, 7\/165) recipients experienced HBV recurrence at a median time of 19 months (range 5\u201336 months) following transplantation. Six of seven cases of HBV recurrence were treated with lamivudine before transplantation for a median period of 15 months (range 0.6\u201330 months). Eighteen (24.6%, 18\/73) patients had HCC recurrences after transplantation. Of the four patients with both HCC and HBV recurrence, three experienced HBV recurrence after recurrence of HCC. The clinical factor associated with HBV recurrence in the total cohort (n\u2009=\u2009165) was the duration of antiviral treatment (over 6 months) before transplantation (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). In the HCC group, HCC recurrence after transplantation (<jats:italic>P<\/jats:italic>\u2009<jats:italic>=<\/jats:italic>\u20090.002), tumor burden before transplantation (<jats:italic>P<\/jats:italic>\u2009=\u20090.005), and postoperative adjuvant chemotherapy (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), were additional factors for HBV recurrence. Combination therapy of HBIg and antiviral drugs was effective over 3 years regardless of the pretransplantation viral load. However, the possible recurrence of HBV needs to be monitored cautiously in patients treated with long\u2010term (over 6 months) lamivudine. J. Med. Virol. 80:1891\u20131899, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21324","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T06:31:05Z","timestamp":1222237865000},"page":"1891-1899","source":"Crossref","is-referenced-by-count":18,"title":["Role of long\u2010term lamivudine treatment of hepatitis B virus recurrence after liver transplantation"],"prefix":"10.1002","volume":"80","author":[{"given":"Hyun Young","family":"Woo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Won","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Ran","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si 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