{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:47:36Z","timestamp":1791334056186,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The extent to which human immunodeficiency virus (HIV\u20101) infection impacts on the ability to mount an effective immune response to HPV is unknown, but is relevant in planning HPV vaccine strategies for HIV\u20101 infected individuals. This longitudinal study investigated changes shortly after HIV\u20101 seroconversion on cervical HPV types and HPV\u201016 antibody responses in serum and at the cervix of female sex workers. Typing of HPV DNA from cervical cells was done prior to HIV\u20101 seroconversion and within 1 year and greater than 2 years after HIV\u20101 seroconversion. Antibody determinations on serum and cervico\u2010vaginal rinse samples were by HPV\u201016 virus\u2010like particle\u2010based, enzyme\u2010linked immunosorbent assay. Of 104 women tested, 40 (38.4%) became HIV\u20101 seropositive (HIV\u2010positive) during the course of the study. Shortly after HIV\u20101 seroconversion a significant increase in multiple (&gt;1) HPV infection (OR 4.0, 95% CI 1.3\u201311.9) was observed compared with HIV\u20101 seronegative (HIV\u2010negative) women and certain changes in HPV type infection. HIV\u20101 seroconversion resulted in a reduced prevalence of serum HPV\u201016 IgA and cervico\u2010vaginal IgA and IgG but an increased prevalence of serum HPV\u201016 IgG. All HIV\u2010positive women had been exposed to HPV\u201016 as all displayed serum HPV\u201016 IgG. Serum HPV\u201016 responses were maintained at a high magnitude in the presence of HPV\u201016 infection irrespective of HIV infection, but decreased in the absence of HPV\u201016 infection. In conclusion, HIV\u20101 seroconversion in sex workers rapidly increased cervical HPV infection and caused a reduced ability to produce cervical HPV\u201016 antibodies but a continued ability to generate serum IgG antibodies. J. Med. Virol. 81:203\u2013210, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21343","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T22:38:39Z","timestamp":1230071919000},"page":"203-210","source":"Crossref","is-referenced-by-count":19,"title":["HIV\u20101 seroconversion promotes rapid changes in cervical human papillomavirus (HPV) prevalence and HPV\u201016 antibodies in female sex workers"],"prefix":"10.1002","volume":"81","author":[{"given":"Dianne J.","family":"Marais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Carrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Ramjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patti","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Lise","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/323081"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2002.01118.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.5.927"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.3.245"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(02)84008-8"},{"key":"e_1_2_1_7_1","first-page":"472","article-title":"Frequent detection of human papillomavirus 16 E2\u2010specific T\u2010helper immunity in healthy subjects","volume":"62","author":"de Jong A","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.10.3020-3027.1998"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.1.357-361.2000"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2005.21.285"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/342972"},{"key":"e_1_2_1_12_1","first-page":"483","article-title":"Regression of cervical intraepithelial neoplasia and loss of human papillomavirus (HPV) infection is associated with cell\u2010mediated immune responses to an HPV type 16 E7 peptide","volume":"11","author":"Kadish AS","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(01)82007-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199702)51:2<126::AID-JMV7>3.0.CO;2-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<403::AID-JMV7>3.0.CO;2-6"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/315815"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2006.04.009"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0588"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00561.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/154407370601900120"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.120"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331534"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.7.3390-3396.1998"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.4.511-519.2006"},{"key":"e_1_2_1_25_1","unstructured":"SitasF BlaauwD TerblancheM MadhooJ CarraraH.1998.Incidence of histological diagnosed cancer in South Africa 1992. 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