{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:57:20Z","timestamp":1791118640505,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Between 1999 and 2007 1,388 stool specimens from patients with acute flaccid paralysis or aseptic meningitis were submitted to the Austrian reference laboratory for poliomyelitis. Samples (201) yielded non\u2010poliovirus enterovirus in culture. One hundred eighty\u2010one viruses were available for typing and 78 isolates which remained serologically untyped were further analyzed by CODEHOP\u2010PCR and sequencing of the VP1 gene and the 5\u2032\u2010untranslated region (5\u2032\u2010UTR). Typing revealed an Echovirus 30 outbreak in northwestern Austria in 2000, which was in accordance with the situation in Europe, and no dramatic seasonal changes of Coxsackie viruses were observed. In 2002\/2003 a small outbreak of enterovirus 71 (EV71), affected 12 patients in the province of Styria. This virus was identified as genotype C1 and appeared to be genetically distinct from the isolates observed in 2001\/2002 in Vienna. In 2004 two unrelated cases occurred in Lower Austria, which were identified as genotype C4, which has been described associated with high mortality most recently in China. In contrast to the situation in Asia the detected EV71 cases were not associated with hand\u2013foot\u2013mouth disease, but with serous meningitis only. This was surprising as a recent publication suggested a reduced neurovirulence of C1 genotype in children in Norway, presumably due to alterations in 5\u2032\u2010UTR and polymerase gene. However, comparing the 5\u2032\u2010UTR of the Austrian isolates and established virulent reference strains to the Norwegian isolate and an attenuated EV71 laboratory strain we did not find an indication that the genotype C1 possesses a RNA structure in its 5\u2032\u2010UTR leading to reduced neurovirulence. J. Med. Virol. 81:317\u2013324, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21374","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T22:38:21Z","timestamp":1230071901000},"page":"317-324","source":"Crossref","is-referenced-by-count":86,"title":["Epidemiology of enterovirus types causing neurological disease in Austria 1999\u20132007: Detection of clusters of echovirus 30 and enterovirus 71 and analysis of prevalent genotypes"],"prefix":"10.1002","volume":"81","author":[{"given":"Birgit","family":"Ortner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiao\u2010Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingomar","family":"Mutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Wewalka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Allerberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh\u2010Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartwig P.","family":"Huemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80784-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(00)00065-2"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.02.008"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0904.020395"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-2-74"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10096-003-0896-4","article-title":"Three ECHO virus serotypes responsible for outbreak of aseptic meningitis in Rhone\u2010Alpes region, France","volume":"22","author":"Chomel JJ","year":"2003","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01317504"},{"key":"e_1_2_1_9_1","first-page":"205","article-title":"Enterovirus 71: The virus, its infections and outbreaks","volume":"33","author":"Ho M","year":"2000","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01745.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0903.020285"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20534"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2002.tb00601.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.12.6171-6175.2005"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01314873"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00542-06"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.1941-1948.1999"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.79789-0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/511073"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90259-6"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.7.1628"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20917"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-005-0684-9"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10412"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268802008191"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21006"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1311.070632"},{"key":"e_1_2_1_28_1","volume-title":"Polio Laboratory Manual","author":"World Health Organization","year":"2004"},{"key":"e_1_2_1_29_1","unstructured":"World Health Organization.2008.Enterovirus in China. 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