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Cytokine testing demonstrated elevated cell\u2010mediated Th1 (IFN\u2010\u03b3, IL\u201012, sTNFR1, CXCL10, CXCL9 and CCL3) and humoral Th2 (IL\u20104) immune responses. Serum antibodies to EBV virus capsid antigen (VCA) IgM and IgG antibodies were detected, together with a raised EBV DNA level (up to about 70,000 DNA copies\/mL) in the acute phase of the illness. This EBV DNA load decreased rapidly in response to treatment with a combination of foscarnet, intravenous immunoglobulin and prednisolone, and the boy's symptoms settled eventually after approximately 50 days of illness, following this combined antiviral and immune\u2010modulating therapy. Detailed immunological, virological, haematological and biochemical laboratory parameters are presented to document this patient's severe EBV disease and eventual recovery. J. Med. Virol. 81:99\u2013105, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21383","type":"journal-article","created":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T15:57:05Z","timestamp":1227283025000},"page":"99-105","source":"Crossref","is-referenced-by-count":10,"title":["Cytokine responses in a severe case of glandular fever treated successfully with foscarnet combined with prednisolone and intravenous immunoglobulin"],"prefix":"10.1002","volume":"81","author":[{"given":"Christine","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie C.K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.C. 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