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The samples included histologically normal cervical epithelium, human papillomavirus (HPV) induced low\u2010grade and high\u2010grade pre\u2010malignant lesions and cervical cancers. All samples were tested for HPV DNA using nested PCR. Forty\u2010nine of the 50 tissue samples tested positive for HPV, 27 tissue samples (54%) were HPV\u201016 positive and 4 samples (8%) were HPV\u201018 positive. The immunohistochemistry results detected different expression levels of the various proteins in basal epithelial cells in histologically normal epithelium followed by an increase in expression in the intermediate layers, whereas the superficial layers remained negative for all tested RNA\u2010binding proteins. Expression of all RNA\u2010binding proteins increased in neoplastic lesions and highest expression was detected in cervical cancers. p16INK4a had a stronger association with high\u2010grade lesions when compared with the RNA\u2010binding proteins. The expression profile of the RNA\u2010binding proteins is similar to PCNA expression in histologically normal epithelium as well as in lesions (low\u2010grade and high\u2010grade) and cervical cancers. As PCNA expression has been suggested to mimic HPV E6\/E7 expression in cervical epithelium, the results suggest the RNA\u2010binding protein analyzed here regulate HPV early gene expression directly and late gene expression indirectly. J. Med. Virol. 81:897\u2013907, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21406","type":"journal-article","created":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T15:42:51Z","timestamp":1237909371000},"page":"897-907","source":"Crossref","is-referenced-by-count":51,"title":["Increased expression of cellular RNA\u2010binding proteins in HPV\u2010induced neoplasia and cervical 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