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From 2002 to 2006, 72 reported cases of acute hepatitis E seropositive for anti\u2010HEV IgM in Taiwan were enrolled for investigation. Acute phase serum samples were collected for detection of HEV RNA, HBV DNA, HCV RNA, and GBV\u2010C RNA by PCR. The results showed that viral sequences of HEV, HBV, HCV and GBV\u2010C were detected in 54 (75%), 21 (29.2%), 9 (12.5%), and 22 (30.6%) of cases, respectively. Acute hepatitis A co\u2010infection was excluded in all patients because none were seropositive for anti\u2010HAV IgM and, nine patients (12.5%) did not seroconvert to anti\u2010HEV IgG. These results suggest that serum markers did not correlate completely with viremia in the diagnosis of acute HEV infection. Multiple viruses may co\u2010infect with acute hepatitis E virus in Taiwan. Detection of hepatitis E viremia together with seropositivity for anti\u2010HEV IgM and followed by seroconversion to anti\u2010HEV IgG should be included in the diagnostic criteria for HEV infection. J. 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Virol. 81:1734\u20131742, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21442","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T20:40:35Z","timestamp":1250800835000},"page":"1734-1742","source":"Crossref","is-referenced-by-count":12,"title":["Acute hepatitis E virus infection in Taiwan 2002\u20132006 revisited: PCR shows frequent co\u2010infection with multiple hepatitis 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