{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:12:11Z","timestamp":1765887131488},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T00:00:00Z","timestamp":1240185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prompted by cases of acute hepatitis in expatriate workers presenting at Alkhor Hospital, Qatar, a limited prospective observational study was conducted from July 2005 to June 2006 to determine the epidemiological and clinical features of patients (predominantly Nepalese) presenting with acute hepatitis. Countrywide during that period samples from 86 Nepalese presenting at different centers were found to be anti\u2010HEV IgG positive and 50 of these were also positive for anti\u2010HEV IgM. Fifty\u2010eight of those Nepalese were seen and treated at Alkhor Hospital and of them 43 were confirmed as cases of acute HEV, being positive for both anti\u2010HEV IgM and IgG. The remaining 15 were diagnosed as probable cases of acute HEV on the basis of clinical and epidemiological similarity. It seems likely that transit in Kathmandu in reportedly unsanitary conditions was the focus of infection. In some of those examined at Alkhor, ultrasound detected a thickened gallbladder wall in 30 of 39 (76.9%) with two cases having clinical acalcular cholecystitis. Higher levels of alanine aminotransferase and aspartate aminotransferase were associated with severe disease and derangement in coagulation. On the available evidence hepatitis E was imported by expatriate workers and it is clear that medical screening of these workers pre\u2010 and post\u2010arrival must be improved to prevent further outbreaks. It is also essential that health care workers in Qatar are made aware of this ongoing problem of imported HEV and understand the variable presentation of the condition. J. Med. Virol. 81:1047\u20131051, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21474","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T05:18:47Z","timestamp":1240291127000},"page":"1047-1051","source":"Crossref","is-referenced-by-count":17,"title":["Hepatitis E in Qatar imported by expatriate workers from Nepal: Epidemiological characteristics and clinical manifestations"],"prefix":"10.1002","volume":"81","author":[{"given":"Abdulsalam Saif","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulatif","family":"Alkhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyal","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wisam","family":"Ghadban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajayeb","family":"Almarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.1997.00145.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/499107"},{"key":"e_1_2_1_4_1","first-page":"245","article-title":"Hepatitis A and pleural effusion in children","volume":"117","author":"Brik T","year":"1989","journal-title":"Harefuah"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01079-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/517296"},{"key":"e_1_2_1_7_1","first-page":"78","article-title":"Acute viral acalculous cholecystitis due to viral hepatitis A","volume":"58","author":"Dalg\u0131\u00e7 N","year":"2005","journal-title":"Ankara \u00dcniversitesi T\u0131p Fak\u00fcltesi Mecmuas\u0131"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890170409"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-5-199403010-00008"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200307000-00020"},{"key":"e_1_2_1_11_1","first-page":"787","article-title":"Hepatitis E virus: Current status","volume":"121","author":"Perez\u2010Gracia MT","year":"2003","journal-title":"Med Clin (Barc)"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00858.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2004.11.008"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.061166"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890430416"},{"key":"e_1_2_1_16_1","first-page":"415","article-title":"Ultrasound findings in acute viral hepatitis","volume":"4","author":"Sudamashu KC","year":"2006","journal-title":"Kathmandu Univ Med J"},{"key":"e_1_2_1_17_1","first-page":"109","article-title":"Ultrasound diagnosis of acute viral hepatitis","volume":"52","author":"Zivkovi\u0107 R","year":"1998","journal-title":"Acta Med Croatica"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.21474","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.21474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T10:36:28Z","timestamp":1696761388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.21474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,20]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/jmv.21474"],"URL":"https:\/\/doi.org\/10.1002\/jmv.21474","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,20]]}}}