{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:35:35Z","timestamp":1790271335397,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T00:00:00Z","timestamp":1248220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to investigate the prevalence of human papilloma virus (HPV), herpes simplex virus\u20101\/\u20102 (HSV\u20101\/\u20102), varicella\u2010zoster virus (VZV), Epstein\u2013Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus\u20106\/\u20107 (HHV\u20106\/\u20107) in 23 human nasal polyps by applying PCR. Two types of control tissues were used: adjacent inferior\/middle turbinates from the patients and inferior\/middle turbinates from 13 patients undergoing nasal corrective surgery. EBV was the virus most frequently detected (35%), followed by HPV (13%), HSV\u20101 (9%), and CMV (4%). The CMV\u2010positive polyp was simultaneously positive for HSV\u20101. HPV was also detected in the adjacent turbinates (4%) and the adjacent middle turbinate (4%) of one of the HPV\u2010positive patients. EBV, HSV, and CMV were not detected in the adjacent turbinates of the EBV\u2010, HSV\u2010 or CMV\u2010positive patients. All mucosae were negative for the VZV, HHV\u20106, and HHV\u20107. This is the first study to deal with the involvement of a comparable group of viruses in human nasal polyposis. The findings support the theory that the presence of viral EBV markedly influences the pathogenesis of these benign nasal tumors. The low incidence of HPV detected confirms the hypothesis that HPV is correlated with infectious mucosal lesions to a lesser extent than it is with proliferative lesions, such as inverted papilloma. The low incidence of HSV\u20101 and CMV confirms that these two herpes viruses may play a minor role in the development of nasal polyposis. Double infection with HSV\u20101 and CMV may also play a minor, though causative, role in nasal polyp development. VZV and HHV\u20106\/\u20107 do not appear to be involved in the pathogenesis of these mucosal lesions. J. Med. Virol. 81:1613\u20131619, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21534","type":"journal-article","created":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T19:03:30Z","timestamp":1248289410000},"page":"1613-1619","source":"Crossref","is-referenced-by-count":54,"title":["Prevalence of human papilloma virus and human herpes virus types 1\u20137 in human nasal polyposis"],"prefix":"10.1002","volume":"81","author":[{"given":"Apostolos","family":"Zaravinos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bizakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios A.","family":"Spandidos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,22]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"344","article-title":"Search for the human 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