{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:38:01Z","timestamp":1770338281558,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T00:00:00Z","timestamp":1248220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HPV testing is a valuable tool in cervical cancer screening and efficacy assessment of HPV vaccines. Concordance of specimens from three sites for detection of HPV DNA in the female genital tract was evaluated. At a single visit, the following specimens were collected: an endo\u2010ecto\u2010cervical swab (EEC), labial\/vulvar\/perineal\/perianal swab (LVPP) and cervicovaginal lavage (CVL). Specimens were evaluated with HPV6, HPV11, HPV16, and HPV18 type\u2010 and gene\u2010specific PCR assays. Of the 898 women evaluated at baseline, 232 were HPV PCR positive in at least one specimen. Of these, for HPV6, HPV11, HPV16, and HPV18, respectively, throughout: (a) 70.4%, 40.0%, 65.3%, and 64.1% tested three\u2010site positive; (b) 13.6%, 30.0%, 19.7%, and 18.8% tested two\u2010site positive; and (c) 16.4%, 30.0%, 15.0%, and 17.2% tested single\u2010site positive. For patients who tested single\u2010site positive for HPV6, HPV11, HPV16, or HPV18, respectively, the specimen was: LVPP in 92.3%, 33.3%, 68.2%, and 72.7%; EEC in 0.0%, 33.3%, 18.2%, and 9.1%; and CVL in 7.7%, 33.3%, 13.6%, and 18.2%. Combining results of swab specimens together increases detection of HPV6, HPV11, HPV16, and HPV 18, respectively, to 98.7%, 90.0%, 97.9%, and 96.9%. HPV DNA is detectable from all three sites using type\u2010specific PCR assays; most women who tested positive for a given HPV type were positive for that type in all three specimens. J. Med. Virol. 81:1620\u20131626, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21561","type":"journal-article","created":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T19:02:41Z","timestamp":1248289361000},"page":"1620-1626","source":"Crossref","is-referenced-by-count":7,"title":["Importance of specimen type in detecting human papillomavirus DNA from the female genital tract"],"prefix":"10.1002","volume":"81","author":[{"given":"Christine C.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Li","family":"Liaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn Egil","family":"Skjeldestad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin U.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine T.","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.117"},{"key":"e_1_2_1_3_1","first-page":"111","article-title":"Epidemiological, clinical and virological observations","volume":"20","author":"Basta A","year":"1999","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.11.796"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1128\/JCM.37.10.3316-3322.1999","article-title":"Detection of multiple human papillomavirus types in condyloma acuminata lesions from otherwise healthy and immunosuppressed patients","volume":"37","author":"Brown DR","year":"1999","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/426867"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.1-17.2003"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318064c8c5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199701)51:1<42::AID-JMV7>3.0.CO;2-S"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199903000-00005"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/S1064744901000217"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1997.tb00542.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17398-4"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020586"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199203000-00002"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462981921143"},{"key":"e_1_2_1_17_1","first-page":"36","article-title":"Epidemiological aspects of vaginal intraepithelial neoplasia (VAIN)","volume":"22","author":"Minucci D","year":"1995","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(07)60015-0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.03.013"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961211)68:6<766::AID-IJC13>3.0.CO;2-Z"},{"key":"e_1_2_1_22_1","first-page":"513","article-title":"Comparison of self\u2010collected vaginal, vulvar and urine samples with physician\u2010collected cervical samples for human papillomavirus testing to detect high\u2010grade squamous intraepithelial neoplasia","volume":"163","author":"Sellors JW","year":"2000","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701714703"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(07)60017-4"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70101-7"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_1_27_1","volume-title":"The current status of development of prophylactic vaccines against human papillomavirus infection: Report of a technical meeting","author":"World Health Organization, Department of Vaccines and Other Biologicals, and International Agency for Research on Cancer","year":"1999"},{"key":"e_1_2_1_28_1","unstructured":"World Health Organization.2006.Initiative for vaccine research. 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