{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T20:01:47Z","timestamp":1776110507980,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T00:00:00Z","timestamp":1253577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2013Barr virus genotypes can be distinguished by polymorphic variations in the genes encoding EBNA2, 3A, 3B, and 3C. The immediate early gene BZLF1 plays a key role in modulating the switch from latency to lytic replication and therefore enabling viral propagation. The aim of this study was to investigate and compare BZLF1 promoter sequence (Zp) variation in pediatric infectious mononucleosis (IM) and in pediatric EBV positive lymphoma biopsies. Zp was sequenced from peripheral blood mononuclear cells (PBMC) and throat swabs from 10 patients with IM at the time of diagnosis (D0) and during convalescence; and from 13 lymphoma biopsies. Zp\u2009\u2212\u2009P and Zp\u2009\u2212\u2009V3 variants were found in eight and one IM patients, as well as in five and six tumor biopsies, respectively. A correlation between viral genotype and Zp variant was found significant for Zp\u2009\u2212\u2009V3 and EBV2 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002). One IM patient harbored two concomitant Zp variants. Regardless of anatomical compartment or stage of disease all IM patients displayed the same Zp variant along the course of the study. No new infections or adaptative selection of different variants was evidenced. A new Zp variant (Zp\u2009\u2212\u2009V3\u2009+\u200949) was described in two Hodgkin lymphomas, but not in IM. This is the first study to describe Zp variants compartmentalization in children with acute EBV infection and convalescence in a developing country; and comparing them with Zp variants in pediatric lymphomas from the same geographic area. J. Med. Virol. 81:1912\u20131917, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21616","type":"journal-article","created":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T23:49:06Z","timestamp":1253663346000},"page":"1912-1917","source":"Crossref","is-referenced-by-count":16,"title":["Epstein\u2013Barr virus BZLF1 gene promoter variants in pediatric patients with acute infectious mononucleosis: Its comparison with pediatric lymphomas"],"prefix":"10.1002","volume":"81","author":[{"given":"Mario Alejandro","family":"Lorenzetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina In\u00e9s","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Altcheh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Moscatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samanta","family":"Moroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Andrea","family":"Chabay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Victoria","family":"Preciado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9,22]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"88","article-title":"Prevalencia de la infecci\u00f3n ppor el virus de Epstein\u2010Barr en pacientes pedi\u00e1tricos","volume":"41","author":"Chabay P","year":"1999","journal-title":"Rev Hosp De Ni\u00f1os B Aires"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-004-0311-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(01)00149-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430707"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20129"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.01.015"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0160"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-7-1663"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.23.1757"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-093278"},{"key":"e_1_2_1_12_1","first-page":"2603","volume-title":"Fields virology","author":"Kieff E","year":"2006"},{"key":"e_1_2_1_13_1","first-page":"197","article-title":"Monitoring of cell\u2010free viral DNA in primary Epstein\u2010Barr virus infection","volume":"188","author":"Kimura H","year":"2000","journal-title":"Med Microbiol Immunol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210240"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.04.015"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200406000-00001"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.64.9.4084-4092.1990"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)01129-3"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/498913"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.13.1008"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030194"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.21616","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.21616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:38:47Z","timestamp":1699972727000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.21616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,22]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/jmv.21616"],"URL":"https:\/\/doi.org\/10.1002\/jmv.21616","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,22]]}}}