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B19V DNA was detected in 1\/91 and 0\/50 serum samples from patients with chronic hepatitis C and B, respectively. In contrast, B19V DNA was amplified frequently from explanted end\u2010stage liver tissues (37\/50, 74%) and from routine biopsy samples (14\/32, 44%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). However, there was no significant difference in B19V copy number per cell between these two groups. B19V\u2010specific CD4<jats:sup>+<\/jats:sup> T\u2010cell responses to two dominant MHC\u2010class\u2010restricted epitopes were detected in a similar frequency in healthy anti\u2010B19V\u2010positive individuals (3\/19; 16%) and patients with chronic hepatitis C (3\/13; 23%). These results indicate that B19V can persist in the liver. However, there is no evidence that B19V is a \u201chepatitis virus\u201d worsening liver disease in European patients with chronic hepatitis C. J. Med. Virol. 81:2079\u20132088, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21638","type":"journal-article","created":{"date-parts":[[2009,10,25]],"date-time":"2009-10-25T21:41:55Z","timestamp":1256506915000},"page":"2079-2088","source":"Crossref","is-referenced-by-count":21,"title":["Intrahepatic long\u2010term persistence of parvovirus B19 and its role in chronic viral hepatitis"],"prefix":"10.1002","volume":"81","author":[{"given":"Chun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Heim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Schlaphoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.V.","family":"Suneetha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin A.","family":"Stegmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Fytili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Kandolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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