{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T07:35:37Z","timestamp":1759390537047},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T00:00:00Z","timestamp":1259539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Norovirus (NoV), a single\u2010stranded, positive RNA virus, is an important etiologic agent of acute gastroenteritis in children worldwide. In this study, a total of 434 fecal samples collected from 434 children with acute gastroenteritis in Seoul, between September 2007 and July 2008 were tested to determine the molecular epidemiology of NoVs and characterize recombinant strains by using RT\u2010PCR followed by sequencing. Of the 434 specimens, NoV, rotavirus, and adenovirus were detected in 155 (35.8%), 72 (16.6%), and 19 specimens (4.3%), respectively. NoV GI was detected in 7 specimens (1.6%) and GII in 148 (34.1%) specimens. Phylogenetic analysis of capsid sequences in the GII\u2010positive specimens revealed the presence of the following strains: GII\u20104, 111 (75.0%); GII\u20103, 35 cases (23.6%); GII\u20106b, 1 case; and GII\u201016, 1 case. Most of the GII\u20104 strains were grouped with the GII\u20104\/2006b variant with 98\u2013100% nucleotide identity. Eleven strains were identified as recombinant (GII\u20104\/GII\u20103 in 10 cases and GII\u2010b polymerase\/GII\u201016 capsid in 1 case) by sequencing based on the RdRP and capsid genes. The putative recombination point in the recombinant strains was the ORF\u20101\/ORF2 overlap, located at nucleotide 5,046 with reference to Lordsdale. In conclusion, GII\u20104\/2006b variants were detected predominantly and a new recombinant strain (GII\u20104\/GII\u20103) was found in the Korean children with gastroenteritis. Continuous monitoring of the genetic diversity of NoVs is important to determine the trend of the predominant genotype and new recombinant strain. J. Med. Virol. 82:146\u2013152, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21650","type":"journal-article","created":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T20:04:41Z","timestamp":1259611481000},"page":"146-152","source":"Crossref","is-referenced-by-count":36,"title":["Detection of GII\u20104\/2006b variant and recombinant noroviruses in children with acute gastroenteritis, South Korea"],"prefix":"10.1002","volume":"82","author":[{"given":"Ju\u2010Young","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Hee","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Hun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eung\u2010Soo","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"S336","DOI":"10.1086\/315589","article-title":"Genetic classification of \u201cNorwalk\u2010like viruses\u201d 2000","volume":"181","author":"Ando T","journal-title":"J Infect Dis"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.8.2854-2859.2002"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21182"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1107.041273"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.83321-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.005082-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21458"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02489-06"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21151"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1262-1267.2006"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21308"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.2988-2995.2004"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.9.4836-4839.2005"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(01)00404-9"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/5.2.150"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2008.08.003"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050031"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","unstructured":"LoleKS BollingerRC ParanjapeRS GadkariD KulkarniSS NovakNG IngersollR SheppardHW RaySC.1999.Full\u2010length human immunodeficiency virus type 1 genomes from subtype C\u2010infected seroconverters in India with evidence of intersubtype recombination. 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