{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:32:40Z","timestamp":1700699560469},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T00:00:00Z","timestamp":1259539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Host and\/or viral factors involved in human polyomavirus (HPoV) infection in persons living with HIV remain unknown. A hypothesis is outlined suggesting the importance of the co\u2010receptors CCR5, CCR2, and CXCR4 not only for HIV, but also for HPoV. Functionally capable receptors coded by wild\u2010type (wt) genotypes could facilitate internalization of HPoV in the cell resulting in brain and\/or kidney infection\/s in HIV infected individuals. Forty\u2010nine Bulgarians with HIV, all treated by HAART, without neurological and\/or kidney disorders, were tested for JCV and BKV and genotyped for CCR5 (CCR5del32), CCR2 (CCR2\u201064I), and CXCR4 (SDF1\u20103\u2032A). In 27\/49 (55.1%) individuals a co\u2010infection with HPoV was identified\u2014BKV in 12\/49 (24.5%), JCV\u2014in another 12\/49 (24.5%), and both viruses\u2014in 3\/49 (6.1%). A high frequency of wt CCR5 was found in patients with HPoV (91.7% for BKV and JCV and in 100% with both viruses). V\/V of CCR2 was presented in 75% for BKV and JCV and in 66.7% for BKV plus JCV. SDF1\u20103\u2032G\/G predominated in JCV infected patients (75%), while G\/A and A\/A genotypes were more frequent in patients with BKV (41.7%). Also, 21\/22 (95.4%) persons without HPoV infection were heterozygous for SDF1 and CCR2. The number of individuals bearing wt of all co\u2010receptors in the group of persons not infected with HPoV was lower (<jats:italic>P<\/jats:italic>\u2009=\u20090.03) than that with polymorphism\/s in one or two genes (SDF1 and CCR2) in the same group. The results suggest a probable role of co\u2010receptors used by HIV to facilitate infection with HPoV. J. Med. Virol. 82:8\u201313, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21674","type":"journal-article","created":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T20:04:41Z","timestamp":1259611481000},"page":"8-13","source":"Crossref","is-referenced-by-count":1,"title":["Do human polyoma viruses and human immunodeficiency virus share common 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