{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:35:23Z","timestamp":1775540123411,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010lymphotropic virus 1 (HTLV\u20101)\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) is a complication that affects up to 5% of HTLV\u20101\u2010infected individuals. Several host genetic and viral factors have been associated with the risk of HAM\/TSP. The aim of this study was to evaluate the performance of a prognostic model for HAM\/TSP developed in Japan in a Peruvian population of 71 HAM\/TSP patients and 94 asymptomatic carriers (ACs). This model included age, proviral load (PVL), the presence of <jats:italic>HLA\u2010A*02<\/jats:italic> and <jats:italic>HLA\u2010Cw*08<\/jats:italic> alleles, <jats:italic>SDF\u20101<\/jats:italic> +<jats:italic>801<\/jats:italic>, and <jats:italic>TNF<\/jats:italic>\u2010\u03b1 \u2212863 polymorphisms, and viral subgroup. We describe frequencies for the four host genetic markers and demonstrate the presence of the HTLV\u20101 <jats:italic>tax<\/jats:italic> B subgroup in Peru. Using cross\u2010validation, we show that the predictive ability of the prognostic model, as characterized by the area under the receiver\u2010operating characteristic curve (AUC), does not differ from a model containing PVL only (both AUC\u2009=\u20090.74). We found some suggestive evidence of a protective effect of the <jats:italic>HLA\u2010A*02<\/jats:italic> allele but failed to replicate the associations with the other three genetic markers and with viral subgroup. A logistic model containing PVL, age, gender, and <jats:italic>HLA\u2010A*02<\/jats:italic> provided the best predictive ability in the Peruvian cohort (AUC\u2009=\u20090.79). J. Med. Virol. 82:460\u2013466, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21675","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T19:54:32Z","timestamp":1263930872000},"page":"460-466","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of host genetic and viral factors as surrogate markers for HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis in Peruvian HTLV\u20101\u2010infected patients"],"prefix":"10.1002","volume":"82","author":[{"given":"Michael","family":"Talledo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen 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