{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:58:06Z","timestamp":1758891486286},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Human herpesvirus 6<\/jats:italic> (HHV\u20106) is widespread in the human population by infecting most individuals in early childhood. After primary infection, HHV\u20106 establishes a latent infection by remaining in circulating mononuclear cells of healthy individuals. The HHV\u20106 antibody titer increases after primary infection with measles virus. The present study was undertaken to determine the specific antiviral IgG1, IgG2, IgG3, and IgG4 subclass response patterns to HHV\u20106 in HHV\u20106\u2010seropositive individuals with natural measles virus infection, measles vaccination, and rubella virus infection. The purpose of this study was to examine HHV\u20106\u2010specific IgG isotype response in patients with acute virus coinfection. Serum samples were obtained from individuals who were seropositive for HHV\u20106 after natural primary infection with measles virus during an outbreak, measles vaccination, or rubella virus infection, and from healthy individuals. Sera were examined by indirect immunofluorescence assays for detection of HHV\u20106\u2010specific IgG1, IgG2, IgG3, and IgG4 antibodies. A high percentage (69%) of those infected with measles virus had an HHV\u20106 IgG1 and IgG4 response (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test), whereas persons vaccinated against measles, those infected with rubella, and healthy individuals showed an HHV\u20106 IgG1 response. These results demonstrate that natural measles virus infection induces an HHV\u20106 IgG isotype response, which suggests a shift in immune activity from a Th1 to a Th2 response. J. Med. Virol. 82:396\u2013399, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21702","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T19:52:02Z","timestamp":1263930722000},"page":"396-399","source":"Crossref","is-referenced-by-count":3,"title":["HHV\u20106 IgG4 isotype response following measles infection"],"prefix":"10.1002","volume":"82","author":[{"given":"Leonardo","family":"Ferreyra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Bustos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Biganzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Beatriz","family":"Isa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Sicilia","family":"Don","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Ribechini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Viviana","family":"Nates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Victorio","family":"Pavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0019-2805.2001.01341.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540152029945"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.05.013"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05074-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-83-6-1431"},{"key":"e_1_2_1_7_1","first-page":"25964","article-title":"Human herpesvirus 6 and measles virus employ distinct CD 46 domains for receptor function","volume":"28","author":"Greenstone H","year":"2002","journal-title":"J Biol Chem"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.4049\/jimmunol.162.3.1597","article-title":"Measles virus infection synergizes with IL\u20104 in IgE class switching","volume":"162","author":"Imani F","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_1_9_1","first-page":"90","article-title":"Measles outbreak in C\u00f3rdoba province, Argentina, in 1998","volume":"31","author":"Isa MB","year":"1999","journal-title":"Rev Argen Microbiol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1144603"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(06)70004-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2516(07)80006-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890380409"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91893-4"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.21702","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.21702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T15:36:05Z","timestamp":1700667365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.21702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,19]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/jmv.21702"],"URL":"https:\/\/doi.org\/10.1002\/jmv.21702","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,19]]}}}