{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:03:35Z","timestamp":1777518215485,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An outbreak of aseptic meningitis (AM) occurred in Jinzhai County in Anhui province from April to July in 2005. Totally, 97 children aged 3\u201315 years were hospitalized. To identify the etiologic agent, 77 cerebrospinal fluid specimens (CSF) and 5 fecal specimens were collected from the patients and cultured by human rhabdomyosarcoma (RD) cell line. Thirty isolates of human echovirus 6 (E6) from 27 CSF and 3 fecal specimens were confirmed by neutralization assay and sequencing analysis of the VP1 gene. The homology of VP1 gene among Anhui isolates was 99.7\u2013100.0% and it indicated that this AM outbreak probable caused by a single transmission link of E6. Phylogenetic analysis based on all the available complete VP1 sequences indicated that E6 could be divided into clusters A, B, and C with at least 15% diversity between clusters and the C cluster could be further divided into C1, C2, C3, and C4. The Anhui isolates most resembled a 2005 strain from Russia (25465 Tambov) and belong to C4. This is the first report that E6 was responsible for an outbreak of AM in China. J. Med. Virol. 82:441\u2013445, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21707","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T19:52:47Z","timestamp":1263930767000},"page":"441-445","source":"Crossref","is-referenced-by-count":32,"title":["An aseptic meningitis outbreak caused by echovirus 6 in Anhui province, China"],"prefix":"10.1002","volume":"82","author":[{"given":"Naiying","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aili","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songtao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenBo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800059185"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.4.888"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10096-003-0896-4","article-title":"Three ECHOvirus serotypes responsible for outbreak of aseptic meningitis in Rhone\u2010Alpes region, France","volume":"22","author":"Chomel JJ","year":"2003","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.9.4171"},{"key":"e_1_2_1_6_1","first-page":"1","article-title":"Enterovirus surveillance\u2013United States, 1970\u20132005","volume":"55","author":"Khetsuriani N","year":"2006","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.05.006"},{"key":"e_1_2_1_8_1","first-page":"655","volume-title":"Fields Virology","author":"Melnick J","year":"1996"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.68.1063"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.5.1288-1293.1999"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.1941-1948.1999"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1170-1174.2000"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.1.182-192.2002"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-008-0685-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1128\/CMR.11.1.202","article-title":"Molecular typing of enteroviruses: Current status and future requirements","volume":"11","author":"Peter M","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-77-8-1699"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.971"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1104.040995"},{"key":"e_1_2_1_19_1","first-page":"321","article-title":"Molecular epidemiological analysis of echovirus 19 isolated from an outbreak associated with hand, foot, and mouth disease (HFMD) in Shandong Province of China","volume":"20","author":"Zhu Z","year":"2007","journal-title":"Biomed Environ Sci"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.21707","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.21707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T15:36:13Z","timestamp":1700667373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.21707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,19]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/jmv.21707"],"URL":"https:\/\/doi.org\/10.1002\/jmv.21707","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,19]]}}}