{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:30:08Z","timestamp":1768325408367,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T00:00:00Z","timestamp":1266364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labour, and Welfare of Japan (Grant-in-Aid for Scientific Research)","award":["04010119"],"award-info":[{"award-number":["04010119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Most previous studies aimed at estimating the number of human T\u2010cell leukemia virus type\u20101 (HTLV\u20101) carriers in endemic areas have been based on seroprevalence rates in blood donors; however, this may result in underestimation because of the healthy donor effect. People who have health problem do not donate blood. In the present study, the number of HTLV\u20101 carriers in Nagasaki City was estimated based on the seroprevalence rates in a hospital\u2010based population from Nagasaki University Hospital. In accordance with previous reports, seroprevalence of HTLV\u20101 was higher in females, and year of birth\u2010specific seroprevalence showed a significant annual decline in both genders (<jats:italic>P<\/jats:italic> for trend: &lt;0.0001). The estimated number of HTLV\u20101 carriers in Nagasaki City was 36,983. The incidence of adult T\u2010cell leukemia\/lymphoma (ATLL) among HTLV\u20101 carriers was estimated using data from the Nagasaki Prefectural Cancer Registry. The estimated annual incidence of ATLL was 61 per 100,000 HTLV\u20101 carriers, and the crude lifetime risk of the development was 7.29% for males and 3.78% for females. There is a large pool of HTLV\u20101 carriers aged over 70 years, and a continuing development of cases of ATLL among the elderly is therefore expected. J. Med. Virol. 82:668\u2013674, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21738","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T22:23:41Z","timestamp":1266445421000},"page":"668-674","source":"Crossref","is-referenced-by-count":25,"title":["Trends in HTLV\u20101 prevalence and incidence of adult T\u2010cell leukemia\/lymphoma in Nagasaki, Japan"],"prefix":"10.1002","volume":"82","author":[{"given":"Yoshito","family":"Koga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Iwanaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Soda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Inokuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimeru","family":"Kamihira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<319::AID-IJC4>3.0.CO;2-B"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.40.14"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832403e8"},{"key":"e_1_2_1_5_1","first-page":"515","article-title":"Evaluation 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