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A 14\u2010month study, from January 2006 to February 2007, was undertaken in a hospital in Thailand to determine the prevalence and genetic characterization of NoVs in patients of all ages with acute gastroenteritis. Based on reverse transcription\u2010nested polymerase chain reaction (RT\u2010nested PCR), NoVs were detected in 122 of 273 (44.7%) collected stool samples. Of the 122 NoV\u2010positive samples, 28 (23%) belonged to GI, 79 (64.8%) belonged to GII, and 15 (12.2%) were mixed infections of GI and GII strains. Three NoV GI\u2010positive and 42 NoV GII\u2010positive samples were characterized successfully by DNA sequencing of the RT\u2010nested PCR products and phylogenetic analysis. For NoV GI, two genotypes were identified: GI\u20102 (one sample) and GI\u20106 (two samples). NoV GII could be classified further into five distinct genotypes: GII\u20102 (1 sample), GII\u20103 (3 samples), GII\u20104 (14 samples), GII\u20106 (3 samples), and GII\u201017 (2 samples), and one unclassified genotype (19 samples). All NoV GII\u20104 strains showed 88\u201398% nucleotide identity with NoV GII\u20104 2006b variants reported worldwide. Among genotypes of NoV characterized, one co\u2010infected stool sample exhibited NoVs GI\u20106 and GII\u20104 2006b. This study suggests that there is an important role of NoVs as etiologic agents in patients with acute gastroenteritis. The predominant circulating genotype of NoV infections is GII\u20104 2006b variant. J. Med. Virol. 82: 854\u2013860, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21746","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T04:25:03Z","timestamp":1269491103000},"page":"854-860","source":"Crossref","is-referenced-by-count":37,"title":["Norovirus GII\u20104 2006b variant circulating in patients with acute gastroenteritis in Thailand during a 2006\u20132007 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