{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:09:50Z","timestamp":1721387390340},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T00:00:00Z","timestamp":1271635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The molecular characteristics of hepatitis A virus (HAV) have been studied widely though there is a paucity of data on the correlation with virological and serological findings. In the present study, the whole genome of an Indian HAV strain associated with Guillain\u2013Barr\u00e9 syndrome (GBS) was characterized vis\u2010\u00e0\u2010vis two other Indian HAV genotype IIIA strains, associated with a self\u2010limiting disease. The percentage nucleotide divergence displayed by the Indian strains (CP\u2010IND, PN\u2010IND, and GBS\u2010IND) varied from 3 to 6, whereas the percentage amino acid divergence varied from 0.1 to 0.7 as compared to the other HAV IIIA strains (n\u2009=\u20095) available in the GenBank. The GBS\u2010IND strain showed an increased rate of nonsynonymous substitutions as well as a larger number of unique and heterologous amino acid substitutions compared to the HAV IIIA GenBank strains. These amino acid substitutions in the GBS\u2010IND strain were detected in a nonstructural protein (2C\u2010251F) and the B\u2010cell epitope regions of structural proteins (VP1\u201029E, VP1\u201091S, VP3\u201050Y, and VP4\u20105S). In a comparative analysis of HAV strains, homology\u2010based models of the capsid proteins indicated a localized alteration in the surface charge distribution on the VP1 protein of GBS\u2010IND strain and involvement of its unique amino acid substitutions in the predicted antigenic determinants. Overall, the study suggests that the unique amino acid substitutions in the GBS\u2010IND strain may have contributed to neutralization escape of the virus leading to a longer duration of viremia. J. Med. Virol. 82:913\u2013919, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21757","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T18:07:12Z","timestamp":1271700432000},"page":"913-919","source":"Crossref","is-referenced-by-count":8,"title":["Longer duration of viremia and unique amino acid substitutions in a hepatitis A virus stain associated with Guillain\u2013Barr\u00e9 syndrome (GBS)"],"prefix":"10.1002","volume":"82","author":[{"given":"Madhuri S.","family":"Joshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah S.","family":"Cherian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Bhalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shobha 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