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A U\u2010shaped age\u2010specific prevalence curve with a first peak (prevalence rate, 10%) at 20\u201325 years and a second peak (13%) at 51\u201355 years was observed. Co\u2010infections with multiple types were detected in 32.5% of HPV\u2010positive subjects and without significant variation among different age groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.318). The majority (84.6%) of the positive samples harbored high\u2010 or probable high\u2010risk HPV types, and these types also exhibited a similar U\u2010shaped age\u2010specific prevalence curve. In contrast, low and unknown\u2010risk HPV types remained at a low prevalence (1.5\u20132.5%) throughout the age groups between 20 and 50 years, and with a small peak (4.5%) at 51\u201355 years. HPV 52 was the most common type found in 26.8% of positive samples, followed by HPV 16 (15.5%), HPV 68 (11.4%), HPV 18 and HPV 58 (8.9% each), HPV 54 (8.1%), HPV 53 (7.3%), HPV 39 (6.5%), HPV 33 and HPV 66 (5.7% each). In conclusion, because of the early peak of infection, vaccination and educational campaigns in Macao should start early and target at teenagers. The presence of a second peak containing mainly high\u2010risk HPV types in older women indicates the need to evaluate the cover of the cervical screening programme for older women. Further study to determine the contribution of HPV 52 in high\u2010grade cervical neoplasia and invasive cancers in Macao is warranted. J. Med. Virol. 82:1724\u20131729, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21826","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T05:48:27Z","timestamp":1284443307000},"page":"1724-1729","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence and genotype distribution of cervical human papillomavirus infection in Macao"],"prefix":"10.1002","volume":"82","author":[{"given":"Yuk\u2010Ching","family":"Yip","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karry L.K.","family":"Ngai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heong\u2010Ting","family":"Vong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence 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