{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T18:46:38Z","timestamp":1763232398968},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T00:00:00Z","timestamp":1277164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The oncoprotein Tax was characterized genetically from a large cohort of human T\u2010cell lymphotropic virus type 1 (HTLV\u20101) seropositive individuals from the most endemic region of HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) and HTLV\u20101 infection in Argentina, the province of San Salvador de Jujuy. Sixteen HAM\/TSP patients and 47 HTLV\u20101 healthy carriers were evaluated. Six <jats:italic>Tax<\/jats:italic> genetic polymorphisms were identified and observed in 70.8% of healthy carriers and 62.5% of HAM\/TSP patients. <jats:italic>Tax<\/jats:italic> genetic polymorphisms were not associated with clinical status but A8344C polymorphism statistically provide a borderline protective effect of HAM\/TSP outcome. Nucleotide diversity in healthy carriers was 0.00549, whereas HAM\/TSP virus population revealed a low diversity of 0.00379, suggests a positive selection for Tax protein conservation in this group. It is concluded that <jats:italic>tax<\/jats:italic> genetic polymorphisms do not increase the risk of developing HAM\/TSP in this endemic region. However, in spite of the low prevalence of HTLV\u20101aB genotype, statistical analysis revealed an important correlation of <jats:italic>tax<\/jats:italic> genetic signatures with HTLV\u20101aA trans\u2010continental subgroup. J. Med. Virol. 82:1438\u20131441, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21833","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T09:49:37Z","timestamp":1277372977000},"page":"1438-1441","source":"Crossref","is-referenced-by-count":3,"title":["Correlation of HTLV\u20101 Tax genetic diversity with HTLV\u20101 associated myelopathy\/tropical spastic paraparesis progression and HTLV\u20101a genotypes in an HTLV\u20101 endemic region in Argentina"],"prefix":"10.1002","volume":"82","author":[{"given":"Alena 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