{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:59:01Z","timestamp":1715993941275},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T00:00:00Z","timestamp":1277164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Breast milk contains immunological factors, such as IgA antibody, which help to prevent infectious diseases. A total of 197 paired samples of colostrum and breast milk was collected from postpartum mothers in Gunma City, Japan, and examined for anti\u2010rubella IgA antibody by enzyme\u2010linked immunosorbent assay (ELISA) and Western blotting (WB). The anti\u2010rubella virus IgA ranged from 0.5 to 78.5\u2009U\/ml with a mean of 6.05\u2009U\/ml and a median of 3.6\u2009U\/ml in colostrum, and from 0.5 to 32.7\u2009U\/ml with a mean of 2.74\u2009U\/ml and a median of 2\u2009U\/ml in milk. The differences between the means of titers of total IgA and anti\u2010rubella virus IgA in colostrum and in milk were significant statistically. The levels of anti\u2010rubella virus IgA in both colostrum and breast milk correlated positively with the anti\u2010rubella virus hemagglutination inhibition (HI) titers in the sera of mother, indicating that the levels of these different classes of antibodies correlated. Based on WB, anti\u2010rubella virus IgA in both colostrum and breast milk reacted with the rubella viral protein E1 and C, but not with the E2 protein. J. Med. Virol. 82:1475\u20131479, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21838","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T09:49:37Z","timestamp":1277372977000},"page":"1475-1479","source":"Crossref","is-referenced-by-count":2,"title":["Quantitative and qualitative assay of rubella IgA antibody in breast milk"],"prefix":"10.1002","volume":"82","author":[{"given":"Yuko","family":"Hayakawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mizuguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teryl K.","family":"Frey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ushijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"178","article-title":"Total and specific IgA in colostrum and milk of mothers of Natal\u2010Rio Grande do Norte, Brasil","volume":"20","author":"Araujo ED","year":"2005","journal-title":"Acta Cir Bras"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/497607"},{"key":"e_1_2_6_4_1","first-page":"279","article-title":"Elimination of rubella and congenital rubella syndrome\u2014United States, 1969\u20132004","volume":"54","author":"CDC","year":"2005","journal-title":"Morb Mortal Wkly Rep"},{"key":"e_1_2_6_5_1","first-page":"963","volume-title":"Fields virology","author":"Chantler J","year":"2001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90572-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1128\/jcm.30.9.2323-2329.1992","article-title":"Cellular and humoral immune responses to rubella virus structural proteins E1, E2, and C","volume":"30","author":"Chaye HH","year":"1992","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00919265"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri982"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60328-0"},{"key":"e_1_2_6_11_1","first-page":"1069","volume-title":"Fields virology 5th edition. 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