{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:57:18Z","timestamp":1774987038964,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2013Barr virus (EBV) is related to the development of lymphomas and is also the etiological agent for infectious mononucleosis (IM). Sequence variation of the EBNA1 gene, consistently expressed in all EBV\u2010positive cells, has been widely studied. Based on the amino acid at codon 487 five major EBNA1 variants have been described, two closely related prototypic variants (P\u2010ala and P\u2010thr) and three variant sequences (V\u2010leu, V\u2010val, and V\u2010pro). Sub\u2010variants were then further classified based on mutations other than the originally described. While several studies proposed associations with tumors and\/or anatomical compartments, others argued in favor of a geographical distribution of these variants. In the present study, EBNA1 variants in 11 pediatric patients with IM and 19 pediatric EBV lymphomas from Argentina were compared as representatives of benign and malignant infection in children, respectively. A 3\u2010month follow\u2010up study of EBNA1 variants in peripheral blood cells and in oral secretions of patients with IM was performed. A new V\u2010ala variant which includes five V\u2010ala sub\u2010variants and three new V\u2010leu sub\u2010variants was described. These data favor the geographical association hypothesis since no evidence for a preferential compartment distribution of EBNA1 variants and sub\u2010variants was found. This is the first study to characterize EBNA1 variants in pediatric patients with infection mononucleosis worldwide. J. Med. Virol. 82:1730\u20131738, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21871","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T05:48:27Z","timestamp":1284443307000},"page":"1730-1738","source":"Crossref","is-referenced-by-count":24,"title":["EBNA1 sequences in Argentinean pediatric acute and latent Epstein\u2013Barr virus infection reflect circulation of novel South American variants"],"prefix":"10.1002","volume":"82","author":[{"given":"Mario 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