{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:45:38Z","timestamp":1761392738861},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,3,13]],"date-time":"2002-03-13T00:00:00Z","timestamp":1015977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A real\u2010time polymerase chain reaction was employed to detect and quantitate Epstein\u2010Barr virus (EBV) DNA in tonsils and autologous sera from EBV\u2010seropositive children. EBV DNA was found in 95% of tonsils from 21 children and in 50% from 18 children with serum IgG titers to the virus capsid antigen (VCA) of \u22651:160 and 1:10 to 1:80, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). Tonsils from children with titers \u22651:160 harbored more EBV DNA copies per mg tissue (mean, 1,237; range, &lt;\u20092\u201313,998) than from children with titers 1:10 to 1:80 (mean, 23; range, &lt;\u20092\u2013226; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). By contrast, EBV DNA was detected only in serum from 25% of 20 children with titers \u2265\u20091:160. Thus, ample differences in tonsillar EBV replication are mirrored inconstantly by detectable EBV in autologous serum suggesting that EBV DNA quantitation in tonsils may serve for refined monitoring of individuals at risk of EBV\u2010associated lymphoproliferation. J. Med. Virol. 67:54\u201358, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.2192","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:12:15Z","timestamp":1030317135000},"page":"54-58","source":"Crossref","is-referenced-by-count":18,"title":["Epstein\u2010Barr virus (EBV) DNA levels in palatine tonsils and autologous serum from EBV carriers"],"prefix":"10.1002","volume":"67","author":[{"given":"David","family":"Nadal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Blasius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix K.","family":"Niggli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,3,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90561-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1182\/blood.V85.3.744.bloodjournal853744","article-title":"Morphology, immunophenotype, and distribution of latently and\/or productively infected cells in acute infectious mononucleosis: implications for the interindividual infection route of Epstein\u2010Barr virus","volume":"85","author":"Anagnostopoulos I","year":"1995","journal-title":"Blood"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200366597"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80622-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1078"},{"key":"e_1_2_1_7_1","first-page":"361","article-title":"Presence of Epstein\u2010Barr virus DNA in tonsillar tissues","volume":"25","author":"Brichacek B","year":"1981","journal-title":"Acta Virol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/100.5.502"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430707"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(00)00446-8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-5-1211"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.21.9964-9971.2000"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.1.132-136.1999"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050332"},{"key":"e_1_2_1_15_1","first-page":"1188","article-title":"Quantitative analysis of cell\u2010free Epstein\u2010Barr virus DNA in plasma of patients with nasopharyngeal carcinoma","volume":"59","author":"Lo YMD","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90075-0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.2.712-715.2000"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.2192","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.2192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T11:22:00Z","timestamp":1700306520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.2192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,13]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1002\/jmv.2192"],"URL":"https:\/\/doi.org\/10.1002\/jmv.2192","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,13]]}}}