{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:13:22Z","timestamp":1790201602417,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,3,13]],"date-time":"2002-03-13T00:00:00Z","timestamp":1015977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2010Barr virus (EBV) is a common herpes virus linked to a variety of human neoplasms. In this study, the EBV detection was identified with the paraffin\u2010embedded tissues from 62 non\u2010Hodgkin's lymphomas, 20 Hodgkin's lymphomas, and 48 non\u2010neoplastic tonsils, using PCR for EBNA\u20101 and EBER\u20101 mRNA in situ hybridization for EBER\u20101 mRNA. The isolates were analyzed for type 1\/2, variants C\/D and F\/f, and LMP\u20101 30 bp deletion. EBV was isolated in 31 of 48 (66%) non\u2010neoplastic tonsils, 24 of 42 (57%) B cell lymphomas, in 15 of 20 (75%) T cell lymphomas, and 17 of 20 (85%) Hodgkin's lymphomas. These viruses were classified as type 1 for 81% of non\u2010neoplastic tonsils, 95% of B cell lymphomas, 93% of T cell lymphomas, and 73% of Hodgkin's diseases. Both type 1 and 2 viruses were isolated in one non\u2010neoplastic tonsil and 3 Hodgkin's diseases. Type C virus was predominant in non\u2010neoplastic tonsils (77%) and B cell lymphomas (75%), while type D virus was common in T cell lymphomas (71%) and Hodgkin's diseases (73%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Majority of the viruses detected in non\u2010neoplastic tonsils (93%) and malignant lymphomas (91%) were \u201cF\u201d prototype. LMP\u20101 30 bp deletion was found in high frequency in both non\u2010neoplastic tonsils (92%) and malignant lymphomas (86%). In conclusion, most of EBV found in Korea was type 1, and \u201cDF\u201d genotype was more frequent in T cell lymphomas and Hodgkin's diseases than in non\u2010neoplastic tonsils and B cell lymphomas. LMP\u20101 30 bp deletion did not seem to be associated with malignant lymphomas. J. Med. Virol. 67:59\u201366, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.2193","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:12:15Z","timestamp":1030317135000},"page":"59-66","source":"Crossref","is-referenced-by-count":13,"title":["Characteristics of Epstein\u2010Barr virus isolated from the malignant lymphomas in Korea"],"prefix":"10.1002","volume":"67","author":[{"given":"Insun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui\u2010Ryun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seol\u2010Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Sik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)91202-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.2.462.462"},{"key":"e_1_2_1_4_1","first-page":"213","article-title":"Investigation of Epstein\u2010Barr viral sequences in 41 cases of Burkitt's lymphomas from Egypt: epidemiological correlations","volume":"1","author":"Anwar N","year":"1994","journal-title":"Cancer Mol Biol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199311000-00018"},{"issue":"869","key":"e_1_2_1_6_1","first-page":"874","article-title":"Criteria for the definition of Epstein\u2010Barr virus association in Hodgkin's disease","volume":"6","author":"Armstrong AA","year":"1992","journal-title":"Leukemia"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.0828"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.11.3004.3004"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409049685"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199409000-00009"},{"key":"e_1_2_1_11_1","first-page":"17","article-title":"Genotyping of Epstein Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue","volume":"148","author":"Chen WG","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"e_1_2_1_13_1","first-page":"1315","article-title":"A survey of Epstein\u2010Barr virus gene expression in sporadic non\u2010Hodgkin's lymphomas. 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