{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:22:40Z","timestamp":1753183360014},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T00:00:00Z","timestamp":1290556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to investigate the distribution of human papilomavirus (HPV) genotypes among a group of patients with high\u2010grade squamous intraepithelial lesion (HSIL) or worse cytology. Consequently, the genotype\u2010specific HPV infection in a group of HSIL and invasive cervical cancer (ICC) samples was described. Specimens were collected prospectively from 132 women referred for colposcopic examination. All the women underwent Papanicolaou (Pap) smears and colposcopies and some also underwent cervical excision procedure biopsy. The HPV genotype was determined using the INNO\u2010LiPA assay. Among the 132 genotyped samples, 90.91% (120\/132) were diagnosed HSIL, whereas 9.09% (12\/132) were ICC. From the overall prevalence of HPV in the patients, 77.27% (102\/132) and 22.72% (30\/132) of cases had single and multiple genotype infections, respectively. The most common cases with statistical significance were high\u2010risk HPV (HR\u2010HPV) infections in 128 samples (96.97%), whereas, four individuals (3.03%) barely were low\u2010risk HPV (LR\u2010HPV) infected, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>. The most prevalent genotypes were frequently HPV\u201016 (65\/167; 38.92%, followed by HPV\u201058 (25\/167; 14.97%), HPV\u201018 (18\/167; 10.78%), HPV\u201033 (13\/167; 7.19%), and HPV\u201068 (11\/167; 6.59%). In addition, HPV\u201011 (2\/132; 1.51%) and HPV\u20106 (1\/132; 0.76%) also were observed in this study, which confirmed the high distribution of HR\u2010HPV among women with HSIL and ICC. HPV\u201058; a unique high\u2010risk HPV, is prevalent in a group of HSIL and ICC cases. These data also contribute evidence that HPV\u201016, \u201018, \u201058, \u201033, and \u201068 genotypes are high\u2010risk and high distribution among women with HSIL and ICC. Therefore, HPV\u201058, HPV\u201033, and HPV\u201068 should be considered for development of the next vaccine generation in Thailand. J. Med. Virol. 83:119\u2013126, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21948","type":"journal-article","created":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T13:59:42Z","timestamp":1290607182000},"page":"119-126","source":"Crossref","is-referenced-by-count":8,"title":["Molecular epidemiology of human papillomavirus genotype in women with high\u2010grade squamous intraepithelial lesion and cervical cancer: Will a quadrivalent vaccine be necessary in 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