{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:26:47Z","timestamp":1780352807105,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T00:00:00Z","timestamp":1290556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is little information on JC virus (JCV) infection in renal transplant patients. A long\u2010term prospective follow\u2010up study was conducted to assess the incidence of JCV DNA in the blood of 103 adult renal transplant patients enrolled prospectively between 1 January and 31 December 2006. Patients were monitored until April 2008. JCV DNA was quantified by a real\u2010time polymerase chain reaction in whole blood samples collected regularly for at least 1 year post\u2010transplant. JCV was detected in seven patients (6.8%) (31\/1,487 whole blood samples) at a median time of 139 days post\u2010transplant. The median JC virus load of the first positive DNA blood sample was 3.4\u2009log<jats:sub>10<\/jats:sub>\u2009copies\/ml (1.9\u20135.7\u2009log<jats:sub>10<\/jats:sub>\u2009copies\/ml). Induction therapy were either anti\u2010CD25 monoclonal antibodies (n\u2009=\u20095) or antithymocyte globulins (n\u2009=\u20092). Post\u2010transplant immunosuppressive treatment included steroids with tacrolimus\/mycophenolate mofetil (MMF) (n\u2009=\u20092), or ciclosporin\/MMF (n\u2009=\u20091), or belatacept\/MMF (n\u2009=\u20094). Two patients were also treated with rituximab. All seven patients infected with JCV had other viral infections(s): BK virus (3), Epstein\u2013Barr virus (2), Cytomegalovirus (1) or both BK virus and Epstein\u2013Barr virus (1). Three patients had BKV\u2010associated nephropathy and decoy cells shedding. JCV infection was not associated with acute rejection episodes or nephropathy, regardless of the virus load. No patient developed progressive multifocal leukoencephalopathy during follow\u2010up. Thus the incidence of JCV infection in renal transplant patients was low and not associated with any specific clinical manifestations. JCV replication must still be diagnosed and differentiated from BK virus infection because of its non\u2010aggressive course. J. Med. Virol. 83:132\u2013136, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21951","type":"journal-article","created":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T13:59:42Z","timestamp":1290607182000},"page":"132-136","source":"Crossref","is-referenced-by-count":22,"title":["JC virus DNA in the peripheral blood of renal transplant patients: A 1\u2010year prospective follow\u2010up in 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