{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:48:08Z","timestamp":1790819288585,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T00:00:00Z","timestamp":1292976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The soluble form of CD30 (sCD30), a member of tumor necrosis factor receptor superfamily, has been used as a marker of disease activity in various lymphomas. Epstein\u2013Barr virus (EBV) is a potent stimulator of CD30 expression. The study aims to evaluate whether sCD30 can be used as a diagnostic marker for EBV\u2010associated infectious mononucleosis (IM) and post\u2010transplant lymphoproliferative disease (PTLD). Plasma from EBV seropositive healthy controls (N\u2009=\u200990), acute IM patients (n\u2009=\u200990), non\u2010PTLD heart\/lung transplant recipients (N\u2009=\u200930) and EBV\u2010positive PTLD patients (N\u2009=\u200923) was tested for sCD30 using a commercially available ELISA kit. EBV DNA was tested by real time quantitative polymerase chain reaction assay. Significantly higher sCD30 levels were observed in acute IM patients (median 242.9\u2009ng\/ml) compared to EBV seropositive controls (median 15.7\u2009ng\/ml; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). These levels were highest in IM patients within 14 days of onset of illness. PTLD patients had significantly higher sCD30 levels (median 94\u2009ng\/ml) than healthy controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and transplant patients (median 27\u2009ng\/ml; <jats:italic>P<\/jats:italic>\u2009=\u20090.0007). EBV DNA was detected mostly in acute IM and PTLD patients. In both cases there was a significant correlation between sCD30 and EBV DNA levels in plasma (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). This study demonstrates that sCD30 and EBV DNA levels can be used as potential markers for diagnosis of IM and PTLD. J. Med. Virol. 83:311\u2013316, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21953","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T23:32:28Z","timestamp":1293060748000},"page":"311-316","source":"Crossref","is-referenced-by-count":41,"title":["Soluble CD30: A serum marker for Epstein\u2013Barr virus\u2010associated lymphoproliferative diseases"],"prefix":"10.1002","volume":"83","author":[{"given":"Tanzina","family":"Haque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turren","family":"Chaggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Schafers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen 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