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However, to date, only partial\u2010length nucleotide sequences are available for the 11 genes of a single human G8P[1] strain, while the partial sequences of two other strains have been reported. The present study reports the first complete genome sequence of a human G8P[1] strain, B12, detected from an asymptomatic infant in Kenya in 1987. By nucleotide sequence identities and phylogenetic analyses, the full\u2010length nucleotide sequences of VP7\u2010VP4\u2010VP6\u2010VP1\u2010VP2\u2010VP3\u2010NSP1\u2010NSP2\u2010NSP3\u2010NSP4\u2010NSP5 genes of strain B12 were assigned to G8\u2010P[1]\u2010I2\u2010R2\u2010C2\u2010M2\u2010A3\u2010N2\u2010T6\u2010E2\u2010H3 genotypes, respectively. Each of the 11 genes of strain B12 appeared to be more related to cognate genes of artiodactyl (ruminant and\/or camelid) and\/or artiodactyl\u2010derived human GAR strains than those of most other rotaviruses. Strain B12 exhibited low levels of genetic relatedness to canonical human GAR strains, such as Wa and DS\u20101, ruling out the possibility of its origin from reassortment events between artiodactyl\u2010like human and true human strains. These observations suggest that strain B12 might have been directly transmitted from artiodactyls to humans. Unhygienic conditions and close proximity of humans to livestock at the sampling site might have facilitated this rare event. This is the first report on a full genomic analysis of a rotavirus strain from Kenya. To our knowledge, strain B12 might be the oldest G8 strain characterized molecularly from the Africa continent. J. Med. Virol. 83:367\u2013376, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21974","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T23:32:28Z","timestamp":1293060748000},"page":"367-376","source":"Crossref","is-referenced-by-count":41,"title":["Full genomic analysis of a G8P[1] rotavirus strain isolated from an asymptomatic infant in Kenya provides evidence for an artiodactyl\u2010to\u2010human interspecies transmission 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