{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T06:14:02Z","timestamp":1700547242889},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T00:00:00Z","timestamp":1295827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010cell lymphotropic virus type I (HTLV\u20101) causes adult T\u2010cell leukemia\/lymphoma and HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP). The different patterns of clinical diseases are thought to be linked to immunogenetic host factors. A variety of autoimmune diseases, such as Sj\u00f6gren's syndrome, have been reported in persons infected with HTLV\u20101, although the precise relationship between these disorders and HTLV\u20101 infection remains unknown. There is no report on the repertoire of HTLV\u20101\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cells in HAM\/TSP patients or carriers with autoimmune diseases, both characterized by an abnormal immune state. In this study, to characterize HTLV\u20101\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cells in asymptomatic HTLV\u20101 carriers, HAM\/TSP patients and carriers with autoimmune diseases, we examined the frequency and diversity of HTLV\u20101\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cells using HTLV\u20101 tetramers. HTLV\u20101 Env\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cells were significantly more frequent in HAM\/TSP and carriers with autoimmune diseases compared with asymptomatic HTLV\u20101 carriers, while the frequency of HTLV\u20101 Tax\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cells was not significantly different among them. CD8<jats:sup>+<\/jats:sup> cells binding to HTLV\u20101 Tax tetramers in carriers with autoimmune diseases were significantly reduced compared with HAM\/TSP patients. This study demonstrates the importance of CD8<jats:sup>+<\/jats:sup> T\u2010cells recognizing HTLV\u20101 Env\u2010tetramers in HAM\/TSP patients and carriers with autoimmune diseases, thereby suggesting that the diversity, frequency and repertoire of HTLV\u20101 Env\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cell clones may be related to the hyperimmune response in HAM\/TSP and carriers with autoimmune diseases, although different immunological mechanisms may mediate the hyperimmunity in these conditions. J. Med. Virol. 83:501\u2013509, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21985","type":"journal-article","created":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T14:07:12Z","timestamp":1295878032000},"page":"501-509","source":"Crossref","is-referenced-by-count":18,"title":["Target epitopes of HTLV\u20101 recognized by class I MHC\u2010restricted cytotoxic T lymphocytes in patients with myelopathy and spastic paraparesis and infected patients with autoimmune disorders"],"prefix":"10.1002","volume":"83","author":[{"given":"Tomohiro","family":"Kozako","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Akimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Toji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohann","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Arima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Suruga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kakushi","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Shimeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Soeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Izumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiharu","family":"Uozumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomichi","family":"Arima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20807"},{"key":"e_1_2_6_3_1","first-page":"1841","article-title":"Clinical manifestations of human T lymphotropic virus type I\u2010infected patients with systemic lupus erythematosus","volume":"34","author":"Akimoto M","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.94"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4049\/jimmunol.151.2.1013","article-title":"Multiple neutralizing B\u2010cell epitopes of human T\u2010cell leukemia virus type 1 (HTLV\u20101) identified by human monoclonal antibodies. 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