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Using baculovirus\u2010insect cell system virus\u2010like particles (VLPs) of NoV genotype GII\u20104 and an uncommon genotype GII\u201012 were produced. These VLPs were used in enzyme\u2010linked immunosorbent assays (ELISA) for detection of NoV\u2010specific immunoglobulin G (IgG) and IgA antibodies in 492 serum specimens from Finnish children 0\u201314 years of age collected between 2006 and 2008. NoV IgG antibody prevalence was 47.3% in the age group 7\u201323 months and increased up to 91.2% after the age of 5 years. Avidity of NoV IgG antibodies was low in the primary infections while high avidity antibodies were detected in the recurrent infections of the older children. In GII\u20104 infections, the homologous antibody response to GII\u20104 VLPs was stronger than to GII\u201012 VLPs but cross\u2010reactivity between GII\u20104 and GII\u201012 was observed. Binding of GII\u20104 VLPs to a putative carbohydrate antigen receptor H\u2010type 3 could be blocked by sera from children not infected with NoV during a waterborne outbreak of acute gastroenteritis. Therefore, protection against NoV infection correlated with strong blocking activity. J. Med. Virol. 83:525\u2013531, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21990","type":"journal-article","created":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T14:07:12Z","timestamp":1295878032000},"page":"525-531","source":"Crossref","is-referenced-by-count":67,"title":["Prevalence of norovirus GII\u20104 antibodies in Finnish children"],"prefix":"10.1002","volume":"83","author":[{"given":"K.","family":"Nurminen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Blazevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Huhti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Koho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.P.","family":"Hyt\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Vesikari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.12.4288-4295.2001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02518-08"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19478-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/367809"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01087-06"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-007-0954-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.4.1022-1025.1993"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.12.3059-3063.1994"},{"key":"e_1_2_6_10_1","first-page":"949","volume-title":"Fields virology","author":"Green KY","year":"2007"},{"key":"e_1_2_6_11_1","first-page":"113","article-title":"Are IgG antibody avidity assays useful in the diagnosis of infectious diseases? 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