{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:37:15Z","timestamp":1773301035742,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1659,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Virol."],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1002\/jmv.22036","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T23:12:54Z","timestamp":1297811574000},"page":"622-629","source":"Crossref","is-referenced-by-count":22,"title":["Investigating an outbreak of acute viral hepatitis caused by hepatitis E virus variants in Karachi, South Pakistan"],"prefix":"10.1002","volume":"83","author":[{"given":"Anis","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuat","family":"Kurbanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer","family":"Elkady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaigham","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahid","family":"Azam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amna","family":"Subhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajjad","family":"Razza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasim","family":"Jafri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningshao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Mishiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,15]]},"reference":[{"key":"10.1002\/jmv.22036-BIB1|cit1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/viro.2000.0819","article-title":"The 3\u2032 end of hepatitis E virus (HEV) genome binds specifically to the viral RNA-dependent RNA polymerase (RdRp)","volume":"282","author":"Agrawal","year":"2001","journal-title":"Virology"},{"key":"10.1002\/jmv.22036-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/hep.22493","article-title":"A 20-year single-center experience with acute liver failure during pregnancy: Is the prognosis really worse?","volume":"48","author":"Bhatia","year":"2008","journal-title":"Hepatology"},{"key":"10.1002\/jmv.22036-BIB3|cit3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.4269\/ajtmh.2002.67.662","article-title":"Epidemic of hepatitis E in a military unit in Abbotrabad, Pakistan","volume":"67","author":"Bryan","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"10.1002\/jmv.22036-BIB4|cit4","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/infdis\/172.4.927","article-title":"Viremia, fecal shedding, and IgM and IgG responses in patients with hepatitis E","volume":"172","author":"Clayson","year":"1995","journal-title":"J Infect Dis"},{"key":"10.1002\/jmv.22036-BIB5|cit5","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/molbev\/msi103","article-title":"Bayesian coalescent inference of past population dynamics from molecular sequences","volume":"22","author":"Drummond","year":"2005","journal-title":"Mol Biol Evol"},{"key":"10.1002\/jmv.22036-BIB6|cit6","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1371\/journal.pbio.0040088","article-title":"Relaxed phylogenetics and dating with confidence","volume":"4","author":"Drummond","year":"2006","journal-title":"PLoS Biol"},{"key":"10.1002\/jmv.22036-BIB7|cit7","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00535-007-2109-x","article-title":"Evaluation of anti-hepatitis E virus (HEV) immunoglobulin A in a serological screening for HEV infection","volume":"42","author":"Elkady","year":"2007","journal-title":"J Gastroenterol"},{"key":"10.1002\/jmv.22036-BIB8|cit8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/rmv.384","article-title":"Hepatitis E virus","volume":"13","author":"Emerson","year":"2003","journal-title":"Rev Med Virol"},{"key":"10.1002\/jmv.22036-BIB9|cit9","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1128\/JVI.00046-06","article-title":"A bicistronic subgenomic mRNA encodes both the ORF2 and ORF3 proteins of hepatitis E virus","volume":"80","author":"Graff","year":"2006","journal-title":"J Virol"},{"key":"10.1002\/jmv.22036-BIB10|cit10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0168-8278(96)80323-0","article-title":"Fulminant hepatic failure in pregnant women: Acute fatty liver or acute viral hepatitis?","volume":"25","author":"Hamid","year":"1996","journal-title":"J Hepatol"},{"key":"10.1002\/jmv.22036-BIB11|cit11","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1053\/jhep.2002.34856","article-title":"Hepatitis E virus superinfection in patients with chronic liver disease","volume":"36","author":"Hamid","year":"2002","journal-title":"Hepatology"},{"key":"10.1002\/jmv.22036-BIB12|cit12","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1365-2893.2006.00774.x","article-title":"Molecular detection and sequence analysis of a new hepatitis E virus isolate from Pakistan","volume":"13","author":"He","year":"2006","journal-title":"J Viral Hepat"},{"key":"10.1002\/jmv.22036-BIB13|cit13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4269\/ajtmh.1989.40.438","article-title":"An outbreak of enterically transmitted non-A, non-B hepatitis in Pakistan","volume":"40","author":"Iqbal","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"10.1002\/jmv.22036-BIB14|cit14","doi-asserted-by":"crossref","first-page":"8848","DOI":"10.1128\/JVI.73.10.8848-8850.1999","article-title":"Evidence that the genomic RNA of hepatitis E virus is capped","volume":"73","author":"Kabrane-Lazizi","year":"1999","journal-title":"J Virol"},{"key":"10.1002\/jmv.22036-BIB15|cit15","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1056\/NEJMoa0706992","article-title":"Hepatitis E virus and chronic hepatitis in organ-transplant recipients","volume":"358","author":"Kamar","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1002\/jmv.22036-BIB16|cit16","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1111\/j.1572-0241.2008.02032.x","article-title":"Does hepatitis E viral load and genotypes influence the final outcome of acute liver failure during pregnancy?","volume":"103","author":"Kar","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1002\/jmv.22036-BIB17|cit17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2307\/3546849","article-title":"Demographic stochasticity and Allee effect on a scale with isotropic noise","volume":"83","author":"Lande","year":"1998","journal-title":"Oikos"},{"key":"10.1002\/jmv.22036-BIB18|cit18","doi-asserted-by":"crossref","first-page":"e1000520","DOI":"10.1371\/journal.pcbi.1000520","article-title":"Bayesian phylogeography finds its roots","volume":"5","author":"Lemey","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"10.1002\/jmv.22036-BIB19|cit19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/rmv.482","article-title":"Phylogenetic analysis of global hepatitis E virus sequences: Genetic diversity, subtypes and zoonosis","volume":"16","author":"Lu","year":"2006","journal-title":"Rev Med Virol"},{"key":"10.1002\/jmv.22036-BIB20|cit20","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/jmv.21484","article-title":"Varying abilities of recombinant polypeptides from different regions of hepatitis E virus ORF2 and ORF3 to detect anti-HEV immunoglobulin M","volume":"81","author":"Ma","year":"2009","journal-title":"J Med Virol"},{"key":"10.1002\/jmv.22036-BIB21|cit21","doi-asserted-by":"crossref","first-page":"e1000198","DOI":"10.1371\/journal.pmed.1000198","article-title":"The global spread of hepatitis C virus 1a and 1b: A phylodynamic and phylogeographic analysis","volume":"6","author":"Magiorkinis","year":"2009","journal-title":"PLoS Med"},{"key":"10.1002\/jmv.22036-BIB22|cit22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.26719\/1996.2.1.121","article-title":"Hepatitis E in Pakistan","volume":"2","author":"Malik Iftikhar Ahmed","year":"1996","journal-title":"East Mediterr Health J"},{"key":"10.1002\/jmv.22036-BIB23|cit23","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1098\/rstb.2001.0866","article-title":"Infectious disease dynamics: What characterizes a successful invader?","volume":"356","author":"May","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1002\/jmv.22036-BIB24|cit24","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/jmv.20393","article-title":"Serological and molecular studies on subclinical hepatitis E virus infection using periodic serum samples obtained from healthy individuals","volume":"76","author":"Mitsui","year":"2005","journal-title":"J Med Virol"},{"key":"10.1002\/jmv.22036-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1128\/JCM.44.4.1581-1583.2006","article-title":"Evaluation of diagnostic assays for hepatitis E virus in outbreak settings","volume":"44","author":"Myint","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1002\/jmv.22036-BIB26|cit26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1128\/JCM.35.1.201-207.1997","article-title":"New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a","volume":"35","author":"Ohno","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1002\/jmv.22036-BIB27|cit27","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1365-2893.2007.00858.x","article-title":"Fulminant liver failure from acute autochthonous hepatitis E in France: Description of seven patients with acute hepatitis E and encephalopathy","volume":"14","author":"Peron","year":"2007","journal-title":"J Viral Hepat"},{"key":"10.1002\/jmv.22036-BIB28|cit28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/molbev\/msg043","article-title":"The epidemiology and iatrogenic transmission of hepatitis C virus in Egypt: A Bayesian coalescent approach","volume":"20","author":"Pybus","year":"2003","journal-title":"Mol Biol Evol"},{"key":"10.1002\/jmv.22036-BIB29|cit29","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1128\/JVI.01501-08","article-title":"Genetic history of hepatitis C virus in East Asia","volume":"83","author":"Pybus","year":"2009","journal-title":"J Virol"},{"key":"10.1002\/jmv.22036-BIB30|cit30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4269\/ajtmh.1997.57.151","article-title":"Water-borne hepatitis E virus epidemic in Islamabad, Pakistan: A common source outbreak traced to the malfunction of a modern water treatment plant","volume":"57","author":"Rab","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"10.1002\/jmv.22036-BIB31|cit31","first-page":"1072","article-title":"Clinical and epidemiological relevance of quantitating hepatitis E virus-specific immunoglobulin M","volume":"9","author":"Seriwatana","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1002\/jmv.22036-BIB32|cit32","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1872-034X.2007.00262.x","article-title":"Development and public release of a comprehensive hepatitis virus database","volume":"38","author":"Shin","year":"2008","journal-title":"Hepatol Res"},{"key":"10.1002\/jmv.22036-BIB33|cit33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1099\/vir.0.19571-0","article-title":"Genetic changes in hepatitis E virus of subtype 1a in patients with sporadic acute hepatitis E in Kathmandu, Nepal, from 1997 to 2002","volume":"85","author":"Shrestha","year":"2004","journal-title":"J Gen Virol"},{"key":"10.1002\/jmv.22036-BIB34|cit34","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/oxfordjournals.molbev.a003872","article-title":"Bayesian selection of continuous-time Markov chain evolutionary models","volume":"18","author":"Suchard","year":"2001","journal-title":"Mol Biol Evol"},{"key":"10.1002\/jmv.22036-BIB35|cit35","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1099\/0022-1317-82-4-883","article-title":"A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: Complete genome sequence and phylogenetic relatedness","volume":"82","author":"Sugauchi","year":"2001","journal-title":"J Gen Virol"},{"key":"10.1002\/jmv.22036-BIB36|cit36","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1159\/000073210","article-title":"Full-length sequences of six hepatitis E virus isolates of genotypes III and IV from patients with sporadic acute or fulminant hepatitis in Japan","volume":"46","author":"Takahashi","year":"2003","journal-title":"Intervirology"},{"key":"10.1002\/jmv.22036-BIB37|cit37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1128\/JCM.43.1.49-56.2005","article-title":"Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) Is highly specific for diagnosis of acute HEV infection","volume":"43","author":"Takahashi","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1002\/jmv.22036-BIB38|cit38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0042-6822(91)90760-9","article-title":"Hepatitis E virus (HEV): Molecular cloning and sequencing of the full-length viral genome","volume":"185","author":"Tam","year":"1991","journal-title":"Virology"},{"key":"10.1002\/jmv.22036-BIB39|cit39","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/hep.20365","article-title":"A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae) and D","volume":"40","author":"Tanaka","year":"2004","journal-title":"Hepatology"},{"key":"10.1002\/jmv.22036-BIB40|cit40","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1099\/vir.0.81661-0","article-title":"Molecular tracing of Japan-indigenous hepatitis E viruses","volume":"87","author":"Tanaka","year":"2006","journal-title":"J Gen Virol"},{"key":"10.1002\/jmv.22036-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1099\/vir.0.010561-0","article-title":"ORF3 protein of hepatitis E virus is essential for virion release from infected cells","volume":"90","author":"Yamada","year":"2009","journal-title":"J Gen Virol"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.22036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jmv.22036\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T01:20:34Z","timestamp":1637284834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.22036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,15]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"URL":"https:\/\/doi.org\/10.1002\/jmv.22036","relation":{},"ISSN":["0146-6615"],"issn-type":[{"value":"0146-6615","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2,15]]}}}