{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:24:30Z","timestamp":1697693070528},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T00:00:00Z","timestamp":1298592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infection with the human papillomavirus (HPV) is responsible for 99.7% of cervical cancers, the second most prevalent neoplasia in women worldwide and the fifth leading cause of death by cancer in this population. In Chile, the incidence rate is 14.4 cases per 100,000 women per year and it is considered a significant public health problem. The natural history of cervical cancer begins gradually from low\u2010grade and high\u2010grade squamous intraepithelial lesions to an invasive disease. In this study the frequency of HPV types was determined by HPV genotyping with reverse line blot hybridization in 200 cytobrushes of women with preneoplastic lesions in a high\u2010risk population. HPV DNA was found in 89% of the lesions (83.3% of low\u2010grade squamous intraepithelial lesions and 93.6% of high\u2010grade squamous intraepithelial lesions). Multiple HPV infections were found in 14.4% and 15.5% of low\u2010 and high\u2010grade lesions, respectively. HPV 16 was the most frequent genotype in single infections, followed by HPV 18. These results show that most of the preneoplastic lesions of the cervix (60%) were associated with HPV 16 and\/or HPV 18, supporting the implementation of an HPV vaccination program in this high\u2010risk population. J. Med. Virol. 83:833\u2013837, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.22057","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T15:57:49Z","timestamp":1298735869000},"page":"833-837","source":"Crossref","is-referenced-by-count":12,"title":["Genotyping of human papillomavirus in cervical intraepithelial neoplasia in a high\u2010risk population"],"prefix":"10.1002","volume":"83","author":[{"given":"Carmen G.","family":"Ili","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Brebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Roa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872007000200004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.11.796"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.1-17.2003"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601024"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600688"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67069-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0812"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1158\/1055-9965.2271.13.12","article-title":"Population\u2010based prevalence and age distribution of human papillomavirus among women in Santiago, Chile","volume":"13","author":"Ferreccio C","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.5.1733-1739.2006"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1749"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj009"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00390.x"},{"key":"e_1_2_5_15_1","first-page":"1382","article-title":"Human papilloma virus (HPV) typing in preneoplastic and neoplastic lesions of the uterine cervix in the IX region\u2010Chile","volume":"131","author":"Melo A","year":"2003","journal-title":"Rev Med Chil"},{"key":"e_1_2_5_16_1","first-page":"639","article-title":"Detection of human papilloma virus in cytologic samples or biopsies of the cervix","volume":"133","author":"Melo A","year":"2005","journal-title":"Rev Med Chil"},{"key":"e_1_2_5_17_1","first-page":"9","article-title":"The role of human papilloma virus in the molecular biology of cervical carcinogenesis","volume":"50","author":"Motoyama S","year":"2004","journal-title":"Kobe J Med Sci"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.12.017"},{"key":"e_1_2_5_20_1","first-page":"11","article-title":"Human papillomavirus (HPV) genotypes in cervix uterine cancer patients in a public hospital and private clinic from Santiago, Chile","volume":"27","author":"Valdivia LI","year":"2010","journal-title":"Rev Chilena Infectol"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.3.779-787.2002"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_5_23_1","unstructured":"WHO\/ICO.2010.WHO\/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human Papillomavirus and Related Cancers in Americas. Summary Report 2010. [September 15 2010]. 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