{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:50:10Z","timestamp":1790895010775,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,4,3]],"date-time":"2002-04-03T00:00:00Z","timestamp":1017792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Arenaviruses can cause hemorrhagic fever and death in primates and guinea pigs, but these viruses are not highly pathogenic for most rodent carriers. In the United States, arenaviruses precipitated outbreaks of hepatitis in captive monkeys, and they present an emerging health threat in the tropical areas of Africa and South America. We describe infection of rhesus macaques with the prototype arenavirus, lymphocytic choriomeningitis virus (LCMV), using the WE strain that has been known to cause both encephalopathy and multifocal hemorrhage. Five macaques were inoculated: two by the intravenous (i.v.) and three by the intragastric (i.g.) route. Whereas the two i.v.\u2010inoculated monkeys developed signs and lesions consistent with fatal hemorrhagic fever, the i.g.\u2010inoculated monkeys had an attenuated infection with no disease. Pathological signs of the primate i.v. infection differ significantly from guinea pig arenavirus infections and make this a superior model for human viral hemorrhagic disease. J. Med. Virol. 67:171\u2013186, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.2206","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"171-186","source":"Crossref","is-referenced-by-count":52,"title":["Hemorrhagic fever occurs after intravenous, but not after intragastric, inoculation of rhesus macaques with lymphocytic choriomeningitis virus"],"prefix":"10.1002","volume":"67","author":[{"given":"Igor S.","family":"Lukashevich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Djavani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan D.","family":"Rodas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Zapata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Usborne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Emerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacque","family":"Mitchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Jahrling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S.","family":"Salvato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/4581290"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/7422"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/321897"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3028-2_19"},{"key":"e_1_2_1_6_1","first-page":"350","article-title":"Electrocardiographic abnormalities in patients with Lassa fever","volume":"92","author":"Cummins D","year":"1989","journal-title":"J Trop Med Hyg"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb04321.x"},{"key":"e_1_2_1_8_1","first-page":"71","article-title":"Experimentalni inhalacni nakaza opic druhu macacus cynomolgus a macacus rhesus virem lymphocitarni choriomeningitidy (kmenem WE) [in Czechoslovakian]","volume":"43","author":"Danes L","year":"1963","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_1_9_1","first-page":"149","article-title":"Sequence comparison of the large genomic RNA segments of two strains of lymphocytic choriomeningitis virus differing in pathogenic potential for guinea pigs","volume":"12","author":"Djavani M","year":"1998","journal-title":"Virus Genes"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00439-9"},{"key":"e_1_2_1_11_1","first-page":"103","article-title":"Mucosal immunization with S. typhimurium expressing Lassa virus NP cross\u2010protects mice from lethal challenge with LCMV","volume":"4","author":"Djavani M","year":"2001","journal-title":"J Hum Virol"},{"key":"e_1_2_1_12_1","first-page":"1262","article-title":"Interactions between viruses and lymphocytes. 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