{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:38:15Z","timestamp":1791992295004,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T00:00:00Z","timestamp":1315872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>RecA homolog<\/jats:italic>, <jats:italic>E. coli<\/jats:italic> (<jats:italic>S. cerevisiae<\/jats:italic>) (<jats:italic>RAD51<\/jats:italic>) may modulate hepatitis B virus (HBV) infection by maintaining genome integrity and mediating homologous DNA repairs. In this study, 16 sequence variations were detected by resequencing all exons, the exon\u2013intron boundary, and promoter regions of the human <jats:italic>RAD51<\/jats:italic> gene in DNA samples of 24 unrelated individuals. To investigate the association of common variations in the <jats:italic>RAD51<\/jats:italic> locus with HBV infection and hepatocellular carcinoma (HCC) occurrence, six common polymorphisms were genotyped in a total of 1,103 Korean HBV cohort, composed of 433 spontaneously recovered patients as controls and 670 chronic carriers of HBV, who were stratified further into 327 cirrhosis\/chronic hepatitis patients and 343 patients with HCC infected with HBV. Logistic analyses revealed no significant association of <jats:italic>RAD51<\/jats:italic> polymorphisms and haplotypes with HBV clearance and HCC occurrence (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Furthermore, with age of infection as an important factor in disease progression to HCC, results from the Cox proportional hazards analysis showed no significant associations between any of the tested <jats:italic>RAD51<\/jats:italic> variants and the age of onset of HCC (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05), suggesting that genetic polymorphisms of <jats:italic>RAD51<\/jats:italic> may not play an important role in clearance of HBV and disease progression to HCC. Although studies in other populations are needed to confirm these findings, this preliminary data may contribute to the current knowledge on the pathogenesis of hepatitis. J. Med. Virol. 83:1892\u20131899, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.22122","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T19:20:23Z","timestamp":1315941623000},"page":"1892-1899","source":"Crossref","is-referenced-by-count":15,"title":["Lack of association of <i>RAD51<\/i> genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population"],"prefix":"10.1002","volume":"83","author":[{"given":"Charisse Flerida A.","family":"Pasaje","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Lae","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun 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