{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:16:58Z","timestamp":1791029818681,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T00:00:00Z","timestamp":1309996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The existence of statistical associations between hepatitis B\u2010related acute\u2010on\u2010chronic liver failure and both hepatitis B virus (HBV) genotype and mutations in the basal core promoter (BCP) and precore (PC) regions needs to be confirmed. A total of 322 patients with a chronic HBV infection, including 77 with hepatitis B\u2010related acute\u2010on\u2010chronic liver failure, 109 with hepatocellular carcinoma (HCC) and 136 with chronic hepatitis B (CHB) were enrolled. The HBV genotype and the presence of mutations in the BCP\/PC regions were determined by direct sequencing, and the frequencies were compared in the three patient groups. Overall, 198\/322 (61.5%) were infected with genotype B and 124\/322 (38.5%) with genotype C. Genotype B was significantly more frequent in patients with acute\u2010on\u2010chronic liver failure than CHB (92.2% vs. 60.3%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). As a contrast, genotype C was more common in patients with HCC than CHB (58.7% vs. 39.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.003). In genotype B patients, the A1762T\/G1764A, A1846T, and G1896A mutations were significantly more prevalent in patients with acute\u2010on\u2010chronic liver failure than CHB (50.7% vs. 28.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.004; 59.2% vs. 34.1%, <jats:italic>P<\/jats:italic>\u2009=\u20090.002; 69.0% vs. 41.5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001, respectively). In multivariate analysis, the risk factors for acute\u2010on\u2010chronic liver failure were genotype B, A1762T\/G1764A, and G1896A. In conclusion, CHB patients with genotype B, G1896A, and A1762T\/G1764A had a higher tendency to develop liver failure than patients with genotype C. Therefore, HBV genotyping and detecting G1896A and A1762T\/G1764A mutations might have important clinical implications as predictive risk factors for hepatitis B\u2010related acute\u2010on\u2010chronic liver failure. J. Med. Virol. 83:1544\u20131550, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.22159","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T17:52:33Z","timestamp":1310061153000},"page":"1544-1550","source":"Crossref","is-referenced-by-count":34,"title":["Hepatitis B virus genotype B with G1896A and A1762T\/G1764A mutations is associated with hepatitis B related acute\u2010on\u2010chronic liver 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