{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:55:10Z","timestamp":1790128510223,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The molecular epidemiological study of hepatitis B virus (HBV) in Indonesia is still limited. This study was aimed to identify the prevalence of HBV pre\u2010S deletion\/insertion mutations, and to assess the association of pre\u2010S deletion mutation with liver disease progression in Indonesia. Pre\u2010S mutations were identified by direct sequencing. Of the 265 subjects, 32 samples (12.1%) harbored pre\u2010S deletion\/insertion mutations. The prevalence of those pre\u2010S mutations was 2.7% (2\/75), 12.9% (8\/62), 16.7% (11\/66), and 17.7% (11\/62) in asymptomatic carrier, chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma groups, respectively. Statistical analysis showed significant difference among them (<jats:italic>P<\/jats:italic>\u2009=\u20090.024). In HBV genotype B (HBV\/B), pre\u2010S1, pre\u2010S1\/S2, and pre\u2010S2 deletion mutations were detected respectively in 3 (17.6%), 4 (23.5%), and 9 (52.9%) of 17 samples. On the other hand, in HBV\/C, 12 of 15 samples (80.0%) showed a pre\u2010S2 deletion mutation, and only 2 samples (13.3%) demonstrated a pre\u2010S1\/S2 deletion mutation. These results suggest that in HBV\/B deletion mutation tends to occur in pre\u2010S1 or pre\u2010S1\/S2 region, while in HBV\/C the deletion mutation usually occurs in the pre\u2010S2 region. Analysis of complete genome of four viruses confirmed that 3 isolates were classified into HBV\/B3, and 1 isolate was HBV\/C1. However, SimPlot and BootScan analyses showed that isolate 08.10.002 was an intragenotypic recombinant between HBV\/B3 and HBV\/B4. As conclusion, the prevalence of HBV pre\u2010S mutations was relatively low in Indonesian patients compared to those from Taiwan, Japan, and other Asian countries. There was a weak association between pre\u2010S deletion mutation and progressive liver disease. J. Med. Virol. 83:1717\u20131726, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.22172","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T12:51:10Z","timestamp":1313067070000},"page":"1717-1726","source":"Crossref","is-referenced-by-count":12,"title":["Low prevalence of hepatitis B virus pre\u2010s deletion mutation in Indonesia"],"prefix":"10.1002","volume":"83","author":[{"given":"Andi","family":"Utama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlinang Diarta","family":"Siburian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Fanany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Destila 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