{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:55:58Z","timestamp":1782226558343,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomaviruses (HPV) constitute one of the most prevalent sexually transmitted infections and are the etiological agents for invasive cervical cancer, the predominant cancer among women in Botswana. However, the prevalence of HPV genotypes in Botswana has yet to be reported.<\/jats:p><jats:p>One hundred thirty\u2010nine endocervical swabs were taken at baseline from HIV\u20101 infected, HSV\u20102 seropositive women enrolled in a longitudinal cohort study designed to assess the influence of herpes simplex virus\u20102 (HSV\u20102) infection on genital tract shedding of HIV\u20101. Extracted DNA was evaluated for the presence of low\u2010risk and high\u2010risk HPV using the Roche Linear Array.<\/jats:p><jats:p>Genotyping identified HPV in 95 of 139 women of which 61\/95 were infected with high\u2010risk HPV and 56\/95 with low\u2010risk HPV. The median number of genotypes was 2 (IQR: 1\u20134). The most prevalent HPV genotype in HIV\u2010infected women was HPV 58. Abnormal cervical cytology was detected in 87\/127 women and was associated with contemporaneous HPV infection (RR\u2009=\u20091.43, 95% CI: 1.05\u20131.93; <jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><jats:p>HPV prevalence was high among HIV\u2010infected women with infection by multiple genotypes being widespread. The associations attributed to specific oncogenic HPV subtypes and cervical squamous intraepithelial lesions presented here provide critical information to inform future vaccine policy within Botswana. J. Med. Virol. 83:1689\u20131695, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.22178","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T12:51:10Z","timestamp":1313067070000},"page":"1689-1695","source":"Crossref","is-referenced-by-count":31,"title":["Prevalence of human papillomavirus genotypes and associated cervical squamous intraepithelial lesions in HIV\u2010infected women in Botswana"],"prefix":"10.1002","volume":"83","author":[{"given":"Iain J.","family":"MacLeod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikhulile","family":"Moyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Lockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukendi","family":"Kayembe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"van Widenfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Makhema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Essex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Wester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181b327e7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283377973"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/526792"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-5-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.6.768"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-4-S1-S8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2003.008060"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9475-z"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25396"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-18"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/505876"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-275"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08151-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_5_16_1","volume-title":"Botswana AIDS Impact Survey III: Statistical Report","author":"NACA","year":"2008"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61248-4"},{"key":"e_1_2_5_18_1","unstructured":"RomanowskiB.2010.Efficacy of the HPV\u201016\/18 adjuvanted vaccine against non\u2010vaccine oncogenic HPV types: End\u2010of\u2010study results. 26th International Papillomavirus Congress (IPC). Montreal Canada."},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603737"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-4-8"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/375783"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/652408"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010094"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.02.003"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji073"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833cbb71"},{"key":"e_1_2_5_27_1","unstructured":"WHO\/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human Papillomavirus and Related Cancers in Botswana. Summary Report 2010. Available atwww.who.int\/hpvcentre."},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2007.01.029"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.22178","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.22178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:09:48Z","timestamp":1700586588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.22178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,11]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1002\/jmv.22178"],"URL":"https:\/\/doi.org\/10.1002\/jmv.22178","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,11]]}}}