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Specifically, among the PYV\u2010positive samples, 83% (34\/41) tested positive for BK polyomavirus (BKV) sequences, whereas 17% (7\/41) were positive for JC\u2010virus. None of the samples were positive for simian virus 40. The presence of BKV DNA in high\u2010grade squamous intraepithelial lesions was confirmed by in situ PCR. BKV sequences were detected more frequently in high\u2010grade squamous intraepithelial lesions, together with the genotype HPV\u201016. The association of BKV with precancerous cervical lesions suggests that this polyomavirus participates with HPV\u201016 in the cell transformation process. Alternatively, BKV might multiply better in HPV\u201016\u2010positive cells from precancerous cervical lesions than in HPV\u201016\u2010negative cells. J. Med. 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