{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:19:08Z","timestamp":1760170748389},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oncogenic human papillomaviruses (HPVs) are the recognized etiological agents of cervical cancer. A number of epidemiological, etiological, and molecular data suggest that variants of the same HPV type are distinct biologically and may confer differential pathogenic risks. Therefore, investigation of genome variants of clinically important HPV types may be important for the identification of pathogenically important variants. In this study, the genomic regions of L1, E6, E7, and long control region (LCR) of HPV 31 and 58, identified in women with abnormal cervical smear, were investigated. Several mutations were identified in the regions examined. Of the mutations found in the L1 region of HPV 31 and 58, the novel mutations described in this study fall within a protein region which may play a critical role in the binding of neutralizing antibodies against different HPV types. No significant association was found between the E6 and E7 mutations of both HPV types and the cytological lesion found. Some mutations found in the LCR of HPV 31 and 58 encompassed known transcription binding sites with possible consequences on the transcription of the oncogenic genes. Intratype genetic characterization of HPV types may help to define the pathogenetic risk of HPV variants. J. Med. Virol. 83:1752\u20131761, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.22201","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T12:51:10Z","timestamp":1313067070000},"page":"1752-1761","source":"Crossref","is-referenced-by-count":18,"title":["Intratype variations of HPV 31 and 58 in Italian women with abnormal cervical cytology"],"prefix":"10.1002","volume":"83","author":[{"given":"Valeria","family":"Cento","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor","family":"Rahmatalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Ciccozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Federico","family":"Perno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ciotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.02.002"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.17.1325"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706380200"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981005)78:2<166::AID-IJC8>3.0.CO;2-X"},{"key":"e_1_2_5_6_1","first-page":"7215","article-title":"Distribution of human papillomavirus types 16 and 18 variants in squamous cellcarcinomas and adenocarcinomas of the cervix","volume":"63","author":"Burk RD","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.21.13630-13640.2005"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.16.1249"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25724"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80449-9"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20727"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.03.033"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20259"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061760"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-001-0399-7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17398-4"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600317"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<34::AID-IJC7>3.0.CO;2-Q"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.10.5914-5922.2005"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600024"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg585"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.08.003"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508455200"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961021)69:5<364::AID-IJC2>3.0.CO;2-3"},{"key":"e_1_2_5_25_1","first-page":"209","article-title":"Use of polymerase chain reaction for the detection of genital human papillomaviruses","volume":"7","author":"Manos MM","year":"1989","journal-title":"Cancer Cells"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990719)82:2<203::AID-IJC9>3.0.CO;2-9"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.01.024"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00486-7"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0702"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.02.003"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21432"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4179"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22481"},{"key":"e_1_2_5_35_1","first-page":"160","volume-title":"The phylogenetic handbook\u2014A practicalapproach to DNA and protein phylogeny","author":"Swofford DL","year":"2003"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr121"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.12.005"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-12-2959"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1086\/657083"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00570-5"},{"key":"e_1_2_5_42_1","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1128\/jvi.69.12.7743-7753.1995","article-title":"Human papillomavirus type 16 variant lineages in United States populations characterized by nucleotide sequence analysis of the E6, L2, and L1 coding segments","volume":"69","author":"Yamada T","year":"1995","journal-title":"J Virol"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.11.6741-6750.2005"},{"key":"e_1_2_5_44_1","first-page":"608","article-title":"p53 codon 72 polymorphism and various human papillomavirus 16 E6 genotypes are risk factors for cervical cancer development","volume":"61","author":"Zehbe I","year":"2001","journal-title":"Cancer Res"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.22201","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.22201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:09:57Z","timestamp":1700586597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.22201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,11]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1002\/jmv.22201"],"URL":"https:\/\/doi.org\/10.1002\/jmv.22201","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,11]]}}}