{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:55:10Z","timestamp":1790128510414,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T00:00:00Z","timestamp":1318982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Few studies have reported on the clinical characteristics of hepatocellular carcinoma (HCC) at the time of diagnosis with regard to pre\u2010S and basal core promoter (BCP) mutations. In this study, the clinical features and prognosis of 126 Korean HCC patients were examined with respect to pre\u2010S deletion and BCP mutations of hepatitis B virus. The proportion of HCC patients according to tumor\u2010node\u2010metastasis stage are as follows: 8.7% in stage I, 31% in stage II, 30.2% in stage III, 21.4% in stage IV\u2010A, and 8.7% in stage IV\u2010B. Overall, 40.5% of HCC patients were treated by surgery or ablation, 59.5% by other methods. Patients were divided according to pre\u2010S deletion and BCP mutations (103 without pre\u2010S deletion, 23 with pre\u2010S deletion; 44 without BCP mutation, 82 with BCP mutation). The tumor characteristics and prognosis were evaluated between the groups, including size, number, type, vessel invasion, portal vein thrombosis, and metastasis. No significant difference in tumor characteristics between the HCC patients with pre\u2010S deletion was observed, compared with the HCC patients without pre\u2010S deletion. In contrast, the survival rate was lower in those with pre\u2010S deletion than in those without it (<jats:italic>P<\/jats:italic>\u2009=\u20090.024). No difference in tumor characteristics was found in non\u2010BCP and BCP mutation patients. Unlike the pre\u2010S deletion group, no difference was observed in survival rate between the non\u2010BCP and BCP patients. In conclusion, pre\u2010S deletion and BCP mutations did not affect the initial tumor features. However, pre\u2010S deletion was an independent risk factor affecting HCC survival. J. Med. Virol. 83:2088\u20132095, 2011. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.22238","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T19:16:32Z","timestamp":1319051792000},"page":"2088-2095","source":"Crossref","is-referenced-by-count":7,"title":["Clinical features and prognosis of hepatocellular carcinoma with respect to pre\u2010S deletion and basal core promoter mutations of hepatitis B virus Genotype C2"],"prefix":"10.1002","volume":"83","author":[{"given":"Han Jak","family":"Ryu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye 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