{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:02:21Z","timestamp":1761580941664},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human T\u2010cell lymphotropic virus type 1 (HTLV\u20101) is the etiological agent of HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP), a progressive disease causing paraparesis of the lower limbs. Only a minority of persons infected with HTLV\u20101 develop HAM\/TSP. Universal susceptibility factors for HAM\/TSP are not known. The viral genotype is similar in asymptomatic carriers and HAM\/TSP patients. High proviral load has been associated consistently with HAM\/TSP, but this factor does not explain fully the presence of disease in HTLV\u20101\u2010infected subjects. Most likely, host genetic factors will play an important role in HAM\/TSP development. A two\u2010stage case\u2010control study was carried out to evaluate the association between HAM\/TSP and candidate single nucleotide polymorphisms (SNPs) from 45 genes in addition to six human leukocyte antigen (HLA) alleles. Ancestry\u2010informative markers were used to correct for population stratification. Several SNPs belonging to <jats:italic>NFKB1A<\/jats:italic> and <jats:italic>NKG2D<\/jats:italic> showed a trend of association in both stages. The fact that the direction of the association observed in the first stage was the same in the second stage suggests that <jats:italic>NFKB1A<\/jats:italic> and <jats:italic>NKG2D<\/jats:italic> may be implicated in the development of HAM\/TSP. Further replication studies in independent HTLV\u20101 patient groups should validate further these associations. J. Med. Virol. 84:319\u2013326, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.22255","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T14:21:31Z","timestamp":1323872491000},"page":"319-326","source":"Crossref","is-referenced-by-count":11,"title":["Possible implication of <i>NFKB1A<\/i> and <i>NKG2D<\/i> genes in susceptibility to HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis in Peruvian patients infected with HTLV\u20101"],"prefix":"10.1002","volume":"84","author":[{"given":"Michael","family":"Talledo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen 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