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The aims of the study were to determine the prevalence of different LMP1 strains and to investigate sequence variation in the C\u2010terminal region of LMP1 in Serbian isolates. This study included 53 EBV\u2010DNA\u2010positive plasma and tissue block samples from patients with mononucleosis syndrome, renal transplantation, and tumors, mostly nasopharyngeal carcinoma. The sequence of the 506\u2010bp fragment of LMP1\u2009C terminus was used for phylogenetic analyses and identification of LMP1 strains, deletions, and mutations. The majority of isolates were non\u2010deleted (66%), and the rest had 30\u2010bp, rare 69\u2010bp, or yet unknown 27\u2010bp deletions, which were not related to malignant or non\u2010malignant isolate origin. However, the majority of 69\u2010bp deletion isolates were derived from patients with nasopharyngeal carcinoma. Less than five 33\u2010bp repeats were found in the majority of non\u2010deleted isolates (68.6%), whereas most 69\u2010bp deletion isolates (75%) had five or six repeats. Serbian isolates were assigned to four LMP1 strains: B95\u20108 (32.1%), China 1 (24.5%), North Carolina (NC; 18.9%), and Mediterranean (Med; 24.5%). In NC isolates, three new mutations unique for this strain were identified. EBV EBNA2 genotypes 1 and 2 were both found, with dominance of genotype 1 (90.7%). This study demonstrated noticeable geographical\u2010associated characteristics in the LMP1 C terminus of investigated isolates. J. Med. Virol. 84:632\u2013642, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23217","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T19:51:29Z","timestamp":1329335489000},"page":"632-642","source":"Crossref","is-referenced-by-count":22,"title":["Carboxy\u2010terminal sequence variation of LMP1 gene in Epstein\u2013Barr\u2010virus\u2010associated mononucleosis and tumors from Serbian 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