{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:06:37Z","timestamp":1766178397643},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The milestone in polio eradication program is to protect effectively children aged 0\u20135 years against the three serotypes of poliovirus. It became necessary to measure the level of neutralizing antibodies to the three poliovirus types in an endemic State in Nigeria. Neutralizing antibodies to the poliovirus types among children aged 0\u20135 years was estimated using micro neutralization assay. Of 129 children, 99 (76.8%), 95 (73.6%), and 95 (73.6%) had neutralizing antibodies with the geometric mean titer of 42.7, 31.3, and 33.2 for the poliovirus type 1, 2, and 3, respectively. Fifty\u2010three percent of the children were protected against the three types of poliovirus. Combination of poliovirus types 1 and 2, 1 and 3, and 2 and 3 were neutralized by 62.8, 58.9, and 61.2% of the children studied, respectively. Only poliovirus type 1 induced antibody titres \u22651:1,024. The number of children with neutralizing antibodies after receiving three doses was significantly higher than those who received one or two doses of oral polio vaccine (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.05). However, those who received more than three doses of oral polio vaccine showed no significant difference in their antibody response. The existence of immunity gap poses a risk of re\u2010emergence of the paralytic poliovirus. The existence of unimmunized and unprotected children along with high birth rate could impede the success of polio vaccination in Nigeria. Elimination of non\u2010compliance to polio vaccine, promotion of health education and documented evidence of vaccination of each child with the parents may facilitate the success of polio eradication program in Nigeria. J. Med. Virol. 84:691\u2013696, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23228","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T19:51:29Z","timestamp":1329335489000},"page":"691-696","source":"Crossref","is-referenced-by-count":8,"title":["A survey for neutralizing antibodies to the three types of poliovirus among children in maiduguri, Nigeria"],"prefix":"10.1002","volume":"84","author":[{"given":"M.M.","family":"Baba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.A.","family":"Haruna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Ogunmola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.","family":"Ambe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.N.","family":"Shidali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Oderinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Marcello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Talle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4314\/nmp.v46i3.28727"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmi075"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.03.009"},{"key":"e_1_2_6_5_1","first-page":"40","article-title":"Risk communication: The over\u2010looked factor in the Nigeria polio immunization boycott crisis","volume":"51","author":"Agbeyegbe L","year":"2007","journal-title":"Nig Med Pract"},{"key":"e_1_2_6_6_1","first-page":"222","article-title":"Apparent global interruption of wild poliovirus type2 transmission","volume":"50","author":"Ceters for Disease Control and Prevention","year":"2001","journal-title":"Morbid Mortal Wkly Rep"},{"key":"e_1_2_6_7_1","first-page":"357","article-title":"Wild poliovirus type1 and type3 importations \u2013 15 countries, Africa, 2008\u20132009","volume":"58","author":"Centers for Diseases Control and Prevention","year":"2009","journal-title":"Morbid Mortal Wkly Rep"},{"key":"e_1_2_6_8_1","first-page":"545","article-title":"Progress toward interruption of wild poliovirus transmission worldwide 2009","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"Morbid Mortal Wkly Rep"},{"key":"e_1_2_6_9_1","first-page":"802","article-title":"Progress toward poliomyelitis eradication\u2010Nigeria, January 2009\u2013July 2010","volume":"59","author":"Centers for Diseases Control and Prevention","year":"2010","journal-title":"Morbid Mortal Wkly Rep"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.3.207"},{"key":"e_1_2_6_11_1","first-page":"72","article-title":"Evaluation of immunity against poliovirus serotypes among children in riverine areas of Delta state, Nigeria","volume":"12","author":"Donbraye E","year":"2011","journal-title":"Afr J Cln Exper Microbiol"},{"key":"e_1_2_6_12_1","unstructured":"Global Polio Eradication Initiative (GPEI).2007.Circulating vaccine\u2010derived poliovirus. 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