{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:35:47Z","timestamp":1773318947817,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis A virus (HAV) is one of the etiologic agents of acute viral hepatitis, an important public health problem worldwide. The aim of this study was to investigate the genetic diversity of HAV in Southwest Iran (Ahwaz). A total of 59 sera were collected from acutely ill patients with anti\u2010HAV IgM antibodies during 2009 and 2010 were tested also by RT\u2010PCR targeting the 5\u2032 NCR for molecular diagnosis and examined in the VP1\u20102A and VP3\u2010VP1 regions for genotyping. Twelve (20%) patients were detected VP1\u20102A by RT\u2010PCR and 10 patients had VP3\u2010VP1. The resulting amplicons were sequenced for genotype identification. All HAV strains were identified as subgenotype IB. Phylogenetic analysis revealed an extensive genetic heterogeneity among the strains. Seven hundred sixty\u2010five S\u2192F and 788 K\u2192R amino acid substitutions in IRI49 isolate were found. It is concluded that subgenotype 1b is the sole genotype HAV in this region. J. Med. Virol. 84:582\u2013586, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23238","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T19:51:29Z","timestamp":1329335489000},"page":"582-586","source":"Crossref","is-referenced-by-count":12,"title":["Molecular epidemiology of hepatitis A virus in patients in the ahwaz region of Iran"],"prefix":"10.1002","volume":"84","author":[{"given":"Ahmad","family":"Nejati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manochehr","family":"Makvandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Samarbafzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloofar","family":"Neisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Moradzadegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(20000201)63:2<88::AID-JMV1001>3.0.CO;2-G"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Prevention of hepatitis A through active or passive immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"48","author":"CDC","year":"1999","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10402"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2025"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19532-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.1.38-58.2001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1511.090214"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.01.014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)01304-X"},{"key":"e_1_2_6_11_1","first-page":"1","article-title":"Molecular characterization of hepatitis A virus isolates from environment and clinical samples in Greece","volume":"7","author":"Kokkinos P","year":"2010","journal-title":"Viral J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/BA20080019"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80304-0"},{"key":"e_1_2_6_14_1","first-page":"99","article-title":"Seroprevalence and risk factors of hepatitis A virus infection in Iran: A population based study","volume":"13","author":"Merat SH","year":"2010","journal-title":"Arch Iran Med"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.63-79.2006"},{"key":"e_1_2_6_16_1","first-page":"343","article-title":"Acute hepatitis A virus infection in Turkey","volume":"70","author":"Normann A","year":"2008","journal-title":"J Med Virol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.2.286"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-6-1365"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.23238","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.23238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:55:37Z","timestamp":1700589337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.23238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,15]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/jmv.23238"],"URL":"https:\/\/doi.org\/10.1002\/jmv.23238","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,15]]}}}