{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T05:31:44Z","timestamp":1772947904987,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T00:00:00Z","timestamp":1331856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2013Barr virus (EBV) infection and family history are significant risk factors associated with undifferentiated nasopharyngeal carcinoma. The presence of aberrant immunoglobulin A (IgA) antibodies against specific EBV antigens in healthy individuals can be predictive of the disease. Very limited reports explored the EBV IgA antibody presence within families of sporadic cases of nasopharyngeal carcinoma. This study aimed to determine whether EBV IgA was observed more frequently among family members of sporadic cases of nasopharyngeal carcinoma compared to community controls and evaluated the non\u2010viral factors as determinants of antibody level. First\u2010degree relatives of nasopharyngeal carcinoma patients (n\u2009=\u2009520) and case\u2010matched community controls (n\u2009=\u200986) were recruited. Sera from all individuals were tested in standardized peptide\u2010based EBV IgA ELISA. Data on demographic variables and other exogenous factors were collected using a questionnaire through face\u2010to\u2010face interviews. A similar frequency of EBV IgA (cut\u2010off value\/CoV 0.354) was observed in the first\u2010degree relatives of cases and in community controls (41.2% vs. 39.5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.770). However, with a higher antibody level (OD<jats:sub>450<\/jats:sub>\u2009=\u20091.000; about three times standard CoV), the relatives showed significantly higher frequency (36.9% vs. 14.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.011). When adjusted for all exogenous factors, the strongest factors associated with seropositivity are being a father (odds ratio\/OR\u2009=\u20094.36; 95% confidence interval\/CI\u2009=\u20091.56\u201312.21) or a sibling (OR\u2009=\u20091.89; 95% CI\u2009=\u20091.06\u20133.38) of a case of nasopharyngeal carcinoma. The higher level of EBV IgA seroreactivity in first\u2010degree relatives of sporadic cases of nasopharyngeal carcinoma compared to the general population supports the use of EBV IgA ELISA for screening among family members. J. Med. Virol. 84:768\u2013776, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23263","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T21:13:18Z","timestamp":1331932398000},"page":"768-776","source":"Crossref","is-referenced-by-count":8,"title":["Seroreactivity against Epstein\u2013Barr virus (EBV) among first\u2010degree relatives of sporadic EBV\u2010associated nasopharyngeal carcinoma in Indonesia"],"prefix":"10.1002","volume":"84","author":[{"given":"Susanna Hilda","family":"Hutajulu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawi","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baning 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