{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T15:40:15Z","timestamp":1713973215473},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to explore the factors in inadequate\u2010responders to treatment with adefovir (ADV) with or without genotypic resistance. The reverse\u2010transcriptase (RT) gene of hepatitis B virus (HBV) was sequenced in 161 patients with inadequate\u2010response to ADV and analyzed for HBV genotypes using a phylogenetic approach. Seventy\u2010six patients (47.2%) were found to carry the rtA181V\/T\/S or rtN236T residue substitution, and most of them had viral rebound. In the patients with viral rebound and ADV genotypic resistance, 19 (25.7%) showed rtA181V\/T\/S\u2009+\u2009rtN236T substitutions. In the other patients, it was found that HBV genotypes and cirrhosis influenced the selection of ADV\u2010resistant positions by univariate analysis and multiple logistic regression analysis. The rtN236T was more frequent in patients with genotype B, and the rtA181V\/T\/S was more common in patients with genotype C (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200911.543,<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Multiple logistic regression analysis showed that the rtN236T and time resistant strains occurred during ADV\u2010treatment were statistically significant for influencing rtA181 variation types (<jats:italic>P<\/jats:italic>\u2009=\u20090.007 and<jats:italic>P<\/jats:italic>\u2009=\u20090.024, respectively), and the occurrence of rtA181T was found to be significantly earlier than rtA181V. In conclusion, genotypic resistance was not detected in the majority of primary nonresponders to ADV when compared to the patients with viral rebound. The different HBV genotypes influence the selection of ADV\u2010resistant mutation positions. The rtA181T occurs more frequently in patients with the rtN236T and it occurs earlier when compared to the rtA181V. These findings suggest that early judgment of adequate response and making a decision for interference in patients treated with ADV are of importance in clinical practice. J. Med. Virol. 84: 1030\u20131036, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23270","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T15:05:08Z","timestamp":1337007908000},"page":"1030-1036","source":"Crossref","is-referenced-by-count":2,"title":["Factors influencing inadequate or suboptimal response to adefovir with or without genotypic resistance"],"prefix":"10.1002","volume":"84","author":[{"given":"Xia","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XueMei","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChangJiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GuoHong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HuiFen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuMing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-83-8-2059"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20608"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.06.011"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.04.011"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1155\/2007\/464652","article-title":"Treatment options for hepatitis B","volume":"18","author":"Conly J","year":"2007","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.018"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21189"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.7883\/yoken.JJID.2006.42","article-title":"YMDD mutations and genotypes of hepatitis B virus in northern China","volume":"59","author":"Li D","year":"2006","journal-title":"Jpn J Infect Dis"},{"key":"e_1_2_5_10_1","first-page":"2102","article-title":"A preliminary study of detection of nucleosides\u2010resistant quesispecies in P gene of hepatitis B virus by conformationsensitive gel electrophoresis","volume":"29","author":"Liu L","year":"2007","journal-title":"Acta Acad Med Militaris Tertiae"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2010.01273.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21698"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2005.00613.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00869.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.08.021"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051214"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.01.001"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.07.038"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21253"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00102.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.10.008"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50288"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji043"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.03.005"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.9.3932-3936.2004"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20016"},{"key":"e_1_2_5_27_1","first-page":"535","article-title":"HBV genotype characterization and distribution in patients with HBV\u2010related liver diseases in Zhejiang Province, P.R. 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